磷酸胆碱脂质搭便车近红外 BODIPY 纳米颗粒用于增强光治疗,Journal of Materials Chemistry B

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磷酸胆碱脂质搭便车近红外 BODIPY 纳米颗粒用于增强光治疗
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2023-04-24 , DOI: 10.1039/d3tb00175j
Huafeng Geng ₁ , Wenhai Lin ₂ , Junbao Liu ₁ , Qing Pei ₃ , Zhigang Xie _{3,

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Affiliation

结合光学成像和光治疗的光治疗学引起了广泛的关注。利用近红外（NIR）光同步触发光动力疗法（PDT）和光热疗法（PTT）实现纳米光疗具有挑战性。在此，我们开发了一种多功能治疗诊断纳米平台，由近红外硼二吡咯亚甲基（BODIPY）与噻吩-BODIPY核心和苯-二乙氨基的协同D-π-A结构以及磷酸胆碱脂质共同组装而成。所制备的纳米颗粒（DBNP）表现出理想的近红外吸收、均匀的球形形态和良好的胶体稳定性。精心设计的分子设计和超分子组装赋予 DBNP 理想的 PDT 和 PTT 活性。在808 nm激光照射下，DBNPs有效地产生活性单线态氧和局部高热，光热转换效率为37.6%。DBNPs优异的PDT和PTT性能增强了其强大的体外和体内抗肿瘤作用。此外，这些纳米粒子表现出良好的肿瘤近红外荧光成像能力。总体而言，DBNP 提供了一种利用磷脂提供疏水性光疗分子以增强肿瘤治疗和成像的范例。

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Choline phosphate lipid-hitchhiked near-infrared BODIPY nanoparticles for enhanced phototheranostics

Phototheranostics integrating optical imaging and phototherapy has attracted extensive attention. Achieving nanophototherapeutics with near infrared (NIR)-light synchronously triggered photodynamic therapy (PDT) and photothermal therapy (PTT) is challenging. Herein, we develop a multifunctional theranostic nanoplatform prepared from the co-assembly of NIR boron dipyrromethene (BODIPY) with a cooperative D–π–A structure of a thiophene-BODIPY core and benzene-diethylamino, and a choline phosphate lipid. The as-fabricated nanoparticles (DBNPs) exhibited desirable NIR absorption, uniform spherical morphology and good colloidal stability. The elaborate molecular design and supramolecular assembly endowed DBNPs with desirable PDT and PTT activities. Upon 808 nm laser irradiation, the DBNPs efficiently generated active singlet oxygen and regional hyperpyrexia, with a photothermal conversion efficiency of 37.6%. The excellent PDT and PTT performance of DBNPs boosted the potent in vitro and in vivo anti-tumor effects. In addition, these nanoparticles manifested their good capability of NIR fluorescence imaging of tumors. Overall, the DBNPs provide a paradigm for delivering hydrophobic phototherapy molecules with phospholipids for enhanced tumor treatment and imaging.

更新日期：2023-04-24

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