Acutely damaged lysosomes can regenerate themselves by repurposing damaged membranes. After damage, cytosolic TBC1D15 relocalizes to impaired lysosomes and assembles the autophagic lysosomal reformation machinery to drive this regeneration. This mechanism exemplifies an immediate cellular response to mitigate the crisis of severe lysosomal damage.

中文翻译：

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TBC1D15 驱动严重受损溶酶体的再生

严重受损的溶酶体可以通过重新利用受损的膜来自我再生。损伤后，胞质 TBC1D15 重新定位到受损的溶酶体并组装自噬溶酶体重组机制以驱动这种再生。这种机制举例说明了立即细胞反应以减轻严重溶酶体损伤的危机。