<br>植酸双峰抗菌表面-普鲁士蓝纳米粒子-阳离子聚合物网络,Advanced Science

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植酸双峰抗菌表面-普鲁士蓝纳米粒子-阳离子聚合物网络
Advanced Science ( IF 14.3 ) Pub Date : 2023-04-07 , DOI: 10.1002/advs.202300354
Xiaodong He ₁ , HuaJun Wu ₁ , Yan Wang ₁ , Yunjie Xiang ₁ , Kai Zhang ₁ , Xi Rao ₁ , En-Tang Kang _{1,

2} , Liqun Xu _{1,

3}

Affiliation

表面改性在定制固体材料的功能方面发挥着关键作用。在材料表面引入抗菌功能可以提供额外的保护，防止危及生命的细菌感染。在此，开发了一种基于植酸（PA）表面粘附和静电相互作用的简单且通用的表面改性方法。 PA 首先通过金属螯合与普鲁士蓝纳米颗粒 (PB NP) 功能化，然后通过静电相互作用与阳离子聚合物 (CP) 缀合。借助表面粘附的 PA 和重力效应，所形成的 PA-PB-CP 网络聚集体以不依赖于基材的方式沉积在固体材料上。 CP引起的“接触杀灭”作用和PB NP引起的局部光热效应的协同杀菌作用赋予了基材很强的抗菌性能。在近红外 (NIR) 照射下，细菌的膜完整性、酶活性和代谢功能在与 PA-PB-CP 涂层接触时受到干扰。 PA-PB-CP修饰的生物医学种植体表面在近红外辐射下表现出良好的生物相容性和协同抗菌作用，并在体外和体内消除粘附的细菌。

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Bimodal Antimicrobial Surfaces of Phytic Acid–Prussian Blue Nanoparticles–Cationic Polymer Networks

Surface modification plays a pivotal role in tailoring the functionalities of a solid material. Introduction of antimicrobial function on material surfaces can provide additional protection against life-threatening bacterial infections. Herein, a simple and universal surface modification method based on surface adhesion and electrostatic interaction of phytic acid (PA) is developed. PA is first functionalized with Prussian blue nanoparticles (PB NPs) via metal chelation and then conjugates with cationic polymers (CPs) through electrostatic interaction. With the aid of surface adherent PA and gravitation effect, the as-formed PA–PB–CP network aggregates are deposited on the solid materials in a substrate-independent manner. Synergistic bactericidal effects of “contact-killing” induced by the CPs and localized photothermal effect caused by the PB NPs endow the substrates with strong antibacterial performance. Membrane integrity, enzymatic activity, and metabolism function of the bacteria are disturbed in contact with the PA–PB–CP coating under near-infrared (NIR) irradiation. The PA–PB–CP modified biomedical implant surfaces exhibit good biocompatibility and synergistic antibacterial effect under NIR irradiation, and eliminate the adhered bacteria both in vitro and in vivo.

更新日期：2023-04-07

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