Seven rare noreudesmane sesquiterpenoids (dysoxydenones M-S, 1–7), including three 11,12,13-trinoreudesmanes, three 13-noreudesmanes and one spirovetivane-type sesquiterpenoid, along with two known analogues were isolated from the fruits of Dysoxylum densiflorum. The planar structures were elucidated by a combination of 1D, 2D NMR and HRESIMS analyses. Their absolute configurations were determined by combination of single-crystal X-ray diffraction, CD exciton chirality method and ECD calculation. All compounds were screened for anti-inflammatory activity on LPS-induced RAW 264.7 cells and IL-1β inhibitory activity.

从Dysoxylum densiflorum的果实中分离出七种罕见的 noreudesmane 倍半萜类化合物 (dysoxydenones MS, 1–7 )，包括三种 11,12,13-trinouredesmanes、三种 13-noreudesmanes 和一种 spirovetivane 型倍半萜类化合物，以及两种已知的类似物。通过 1D、2D NMR 和 HRESIMS 分析的组合阐明了平面结构。它们的绝对构型是通过单晶X射线衍射、CD激子手性方法和ECD计算相结合确定的。筛选所有化合物对 LPS 诱导的 RAW 264.7 细胞的抗炎活性和 IL-1 β抑制活性。