<br>熊果酸及其衍生物的治疗潜力和新配方：最新综述,Journal of the Science of Food and Agriculture

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熊果酸及其衍生物的治疗潜力和新配方：最新综述
Journal of the Science of Food and Agriculture ( IF 3.3 ) Pub Date : 2023-01-03 , DOI: 10.1002/jsfa.12423
Priya Namdeo ₁ , Bina Gidwani ₂ , Sakshi Tiwari ₁ , Vishal Jain ₁ , Veenu Joshi ₃ , Shiv Shankar Shukla ₂ , Ravindra Kumar Pandey ₂ , Amber Vyas ₁

Affiliation

植物产生的生物活性代谢物已被用来治疗各种严重和持续性疾病。了解这些生物活性分子的工作原理有可能使研究人员能够针对恶性肿瘤、心脏病和神经系统疾病等疾病提出更好的治疗方法。熊果酸 (UA) 是一种五环三萜类化合物，广泛存在于水果、叶子、草本植物和花朵中。本综述讨论了尿酸的生物和化学方面及其存在、植物来源和生物合成，以及传统和较新的提取技术。由于其在创造新治疗技术方面的生物学功能，UA 是多种医疗状况（包括癌症和其他危及生命的疾病）的演变和医疗管理的可行选择。尽管如此，该物质在水生环境中的溶解度较差，使其不适合医疗用途。这个障碍通过许多不同的方式得到解决。人们发现，将UA纳入各种药物递送方法在这方面非常有效。该综述还介绍了 UA 的特性及其药代动力学，以及 UA 在癌症、炎症和心血管疾病中的治疗应用，以及其抗糖尿病、免疫调节、保肝和抗微生物特性。本综述涵盖了一些与新型纳米载体作为 UA 递送系统相关的最新发现以及与 UA 及其各种衍生物的应用相关的专利。还讨论了UV、HPLC、高效薄层色谱和气相色谱对UA、齐墩果酸等植物成分的分析研究。未来，可以使用各种动物模型在体内探索UA，此外，还需要探索UA的监管状况。 © 2023 化学工业协会。

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Therapeutic potential and novel formulations of ursolic acid and its derivatives: an updated review

Plants produce biologically active metabolites that have been utilised to cure a variety of severe and persistent illnesses. There is a possibility that understanding how these bioactive molecules work would allow researchers to come up with better treatments for diseases including malignancy, cardiac disease and neurological disorders. A triterpene called ursolic acid (UA) is a pentacyclic prevalent triterpenoid found in fruits, leaves, herbs and blooms. The biological and chemical aspects of UA, as well as their presence, plant sources and biosynthesis, and traditional and newer technologies of extraction, are discussed in this review. Because of its biological function in the creation of new therapeutic techniques, UA is a feasible option for the evolution and medical management of a wide range of medical conditions, including cancer and other life threatening diseases. Despite this, the substance's poor solubility in aquatic environments makes it unsuitable for medicinal purposes. This hurdle was resolved in many different ways. The inclusion of UA into various pharmaceutical delivery approaches was found to be quite effective in this respect. This review also describes the properties of UA and its pharmacokinetics, as well as therapeutic applications of UA for cancer, inflammatory and cardiovascular diseases, in addition to its anti-diabetic, immunomodulatory, hepatoprotective and anti-microbial properties. Some of the recent findings related to novel nano-sized carriers as a delivery system for UA and the patents related to the applications of UA and its various derivatives are covered in this review. The analytical study of UA, oleanolic acid and other phytoconstituents by UV, HPLC, high-performance thin-layer chromatography and gas chromatography is also discussed. In the future, UA could be explored in vivo using various animal models and, in addition, the regulatory status regarding UA needs to be explored. © 2023 Society of Chemical Industry.

更新日期：2023-01-03

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