Iron-catalyzed dual decarboxylative coupling of α-amino acids and dioxazolones under visible-light to access amide derivatives,Chemical Communications

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Iron-catalyzed dual decarboxylative coupling of α-amino acids and dioxazolones under visible-light to access amide derivatives
Chemical Communications ( IF 4.3 ) Pub Date : 2022-12-13 , DOI: 10.1039/d2cc03318f
Zhanqun Liang ₁ , Kaifeng Wang ₁ , Qing Sun ₁ , Yuzhu Peng ₁ , Xiaoguang Bao _{1,

2}

Affiliation

An iron-catalyzed decarboxylative C–N coupling of α-amino acids with dioxazolones is described herein to synthesize amide derivatives under visible-light. The desired products can be given in good to excellent yields under simple, mild, and oxidant-free conditions. This protocol provides a practical route for the transformation of α-amino acids to the corresponding amides. Computational studies were carried out to shed light on the mechanism of this reaction.

中文翻译：

可见光下铁催化α-氨基酸和二恶唑酮的双重脱羧偶联以获得酰胺衍生物

本文描述了铁催化的α-氨基酸与二恶唑酮的脱羧 C-N 偶联，以在可见光下合成酰胺衍生物。在简单、温和和无氧化剂的条件下，可以以良好的收率获得所需的产品。该协议为将 α-氨基酸转化为相应的酰胺提供了实用的途径。进行了计算研究以阐明该反应的机理。

更新日期：2022-12-13

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