将强大的 NIR-II 荧光亮度和光热性能结合到用于光疗的单个大 π 共轭分子中,Advanced Science

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将强大的 NIR-II 荧光亮度和光热性能结合到用于光疗的单个大 π 共轭分子中
Advanced Science ( IF 14.3 ) Pub Date : 2022-12-01 , DOI: 10.1002/advs.202204695
Yuanyuan Li ₁ , Yufu Tang _{1,

2} , Wenbo Hu ₃ , Zhen Wang ₁ , Xi Li ₂ , Xiaomei Lu ₂ , Shufen Chen ₁ , Wei Huang _{1,

2,

3} , Quli Fan _{1,

3}

Affiliation

第二近红外（NIR-II，1000-1700 nm）窗口荧光成像引导的光热治疗探针有望用于精确的癌症光疗。然而，目前报道的大多数探针在单个分子中都没有表现出高 NIR-II 荧光亮度（摩尔吸收系数（ε）×量子产率（QY））和光热性能（ε ×光热转换效率（PCE））。在此，通过制造具有刚性分子骨架和柔性侧基的大型π共轭分子 (BNDI-Me)，报道了解决这一挑战的通用策略。拟议的 BNDI-Me 纳米探针可提高ε并同时优化其 QY 和 PCE。因此，高 NIR-II 荧光亮度（ε× QY = 2296 m ⁻¹ cm ⁻¹ ) 和强大的光热性能 ( ε × PCE = 82 000) 被成功地结合到一个小分子中，据了解，这两个参数中的任何一个都优于最好的目前可用的荧光或光热探针。因此，在低全身注射剂量下获得了优异的体内 NIR-II 成像效果和高光热肿瘤抑制率 (81.2%)。这项工作提供了对光物理机制和结构之间关系的进一步见解，并提出了有前途的分子设计指南，用于在单个分子中整合更有效的多种治疗诊断功能。

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Incorporation of Robust NIR-II Fluorescence Brightness and Photothermal Performance in a Single Large π-Conjugated Molecule for Phototheranostics

Second near-infrared (NIR-II, 1000–1700 nm) window fluorescence imaging-guided photothermal therapy probes are promising for precise cancer phototheranostics. However, most of the currently reported probes do not demonstrate high NIR-II fluorescent brightness (molar absorption coefficient (ε) × quantum yield (QY)) and photothermal performance (ε × photothermal conversion efficiency (PCE)) in a single molecule. Herein, a versatile strategy to solve this challenge is reported by fabricating a large π-conjugated molecule (BNDI-Me) with a rigid molecular skeleton and flexible side groups. The proposed BNDI-Me nanoprobe boosts the ε and simultaneously optimizes its QY and PCE. Therefore, high NIR-II fluorescent brightness (ε × QY = 2296 m⁻¹ cm⁻¹) and strong photothermal performance (ε × PCE = 82 000) are successfully incorporated in a single small molecule, and, to the best of knowledge, either of these two parameters is better than the best currently available fluorescent or photothermal probes. Thus, superior NIR-II imaging effect in vivo and high photothermal tumor inhibition rate (81.2%) at low systemic injection doses are obtained. The work provides further insights into the relationship of photophysical mechanisms and structures, and presents promising molecular design guidelines for the integration of more efficient multiple theranostic functions in a single molecule.

更新日期：2022-12-01

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