The immune-modulatory metabolite itaconate is secreted by myeloid-derived suppressor cells and taken up by CD8+ T cells to suppress their proliferation and function. In mice, blocking itaconate production enhances the efficacy of immune checkpoint blockade.

中文翻译：

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代谢物衣康酸盐对 CD8+ T 细胞的抑制作用

免疫调节代谢物衣康酸盐由骨髓来源的抑制细胞分泌，并被 CD8+ T 细胞吸收以抑制其增殖和功能。在小鼠中，阻断衣康酸的产生可增强免疫检查点阻断的功效。