调节碳点的光化学性质用于治疗诊断应用,WIREs Nanomedicine and Nanobiotechnology

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调节碳点的光化学性质用于治疗诊断应用
WIREs Nanomedicine and Nanobiotechnology ( IF 6.9 ) Pub Date : 2022-11-08 , DOI: 10.1002/wnan.1862
Qin Wang ₁ , E Pang ₁ , Qiuxia Tan ₁ , Shaojing Zhao ₁ , Jianing Yi ₂ , Jie Zeng ₃ , Minhuan Lan ₁

Affiliation

碳点（CDs）作为一种新型零维碳基材料，因其易于制备和表面修饰、良好的生物相容性和水溶性以及可调节的光化学性能等优点而受到广泛关注。CD已成为荧光传感、生物成像和癌症治疗领域最有前途的纳米材料之一。如何精确调控CD的光化学性质，特别是吸收、荧光、磷光、活性氧生成和光热转换，是开发用于癌症治疗的高效光治疗的关键。尽管已经发表了许多关于使用 CD 进行癌症治疗的研究，但没有评论关注用于光治疗应用的 CD 光化学特性的调节。在这篇评论中，我们总结了选择合适碳源、杂原子掺杂、最佳反应条件、表面修饰和组装策略等策略，以有效调节碳点的光化学性质，以满足不同实际应用的要求。本综述可能为开发具有优异光治疗性能的 CD 提供一些有价值的见解和新想法。

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Regulating photochemical properties of carbon dots for theranostic applications

As a new zero-dimensional carbon-based material, carbon dots (CDs) have attracted extensive attention owing to their advantages such as easy preparation and surface modification, good biocompatibility and water solubility, and tunable photochemical properties. CDs have become one of the most promising nanomaterials in the field of fluorescent sensing, bioimaging, and cancer therapy. How to precisely regulate the photochemical properties, especially the absorption, fluorescence, phosphorescence, reactive oxygen species generation, and photothermal conversion of the CDs, is the key to developing highly efficient phototheranostics for cancer treatment. Although many studies on cancer therapy using CDs have been published, no review has focused on the regulation of photochemical properties of CDs for phototheranostic applications. In this review, we summarized the strategies such as the selection of suitable carbon source, heteroatomic doping, optimum reaction conditions, surface modification, and assembly strategy to efficiently regulate the photochemical properties of the CDs to meet the requirements of different practical applications. This review might provide some valuable insight and new ideas for the development of CDs with excellent phototheranostic performance.

更新日期：2022-11-08

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