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Reg4+ 深部隐窝分泌细胞在结肠中充当 Lgr5+ 干细胞的上皮生态位 [细胞生物学]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2016-09-13 09:35:48 , DOI: 10.1073/pnas.1607327113
Nobuo Sasaki 1 , Norman Sachs 1 , Kay Wiebrands 1 , Saskia I J Ellenbroek 1 , Arianna Fumagalli 1 , Anna Lyubimova 1 , Harry Begthel 1 , Maaike van den Born 1 , Johan H van Es 1 , Wouter R Karthaus 1 , Vivian S W Li 1 , Carmen López-Iglesias 2 , Peter J Peters 2 , Jacco van Rheenen 1 , Alexander van Oudenaarden 1 , Hans Clevers 1
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富含亮氨酸重复序列的 G 蛋白偶联受体 5 阳性 (Lgr5+) 干细胞位于小肠和大肠的隐窝底部。小肠潘氏细胞向邻近的 Lgr5+ 干细胞提供 Wnt3、EGF 和 Notch 信号。虽然结肠缺乏潘氏细胞,但深隐窝分泌 (DCS) 细胞与 Lgr5+ 干细胞混合...



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更新日期:2016-09-15
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