Nitrogen-based heterocycles have aroused widespread interest due to their reoccurrence in many pharmaceuticals. Amongst these motifs, the enantioenriched lactams are the ubiquitous scaffolds found in myriad biologically active natural products and drugs. Recently, the transition metal-catalyzed asymmetric carbamoylation has been widely employed as a straightforward arsenal for chiral lactam architecture synthesis, including β-lactam and γ-lactam. However, despite the extensive efforts, there still remains no protocol to accomplish the related δ-lactam synthesis. In this manuscript, the Ni-catalyzed enantioselective carbamoylation of unactivated alkenes by the leverage of reductive dicarbofunctionalization strategy allows for the expedient access to two types of mostly common six-membered lactams: 3,4-dihydroquinolinones and 2-piperidinone in high yield and enantioselectivity. This protocol features with good functional group tolerance, as well as broad substrate scope. The newly developed chiral 8-Quinox skeleton ligand is the key parameter for this transformation, which significantly enhances the reactivity and enantioselectivity.

氮基杂环化合物由于在许多药物中反复出现而引起了广泛的兴趣。在这些基序中，对映体富集的内酰胺是在无数生物活性天然产物和药物中普遍存在的支架。最近，过渡金属催化的不对称氨甲酰化已被广泛用作手性内酰胺结构合成（包括β-内酰胺和γ-内酰胺）的简单方法。然而，尽管付出了广泛的努力，仍然没有完成相关δ-内酰胺合成的方案。在这篇手稿中，通过还原二碳官能化策略，镍催化未活化烯烃的对映选择性氨基甲酰化可以以高产率和对映选择性方便地获得两种最常见的六元内酰胺：3,4-二氢喹啉酮和2-哌啶酮。该方案具有良好的官能团耐受性以及广泛的底物范围。新开发的手性8-Quinox骨架配体是这一转化的关键参数，它显着增强了反应活性和对映选择性。