通过模拟胞吐作用调节滑膜巨噬细胞极化以治疗骨关节炎,Advanced Functional Materials

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通过模拟胞吐作用调节滑膜巨噬细胞极化以治疗骨关节炎
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2022-10-09 , DOI: 10.1002/adfm.202207637
Hongbin Yang _{1,

2,

3,

4} , Zhenyan Yu ₄ , Shuaishuai Ji ₄ , Jie Yan ₄ , Yan kong ₁ , Qiang Huo ₄ , Zhijun Zhang _{1,

5} , Yimin Niu _{1,

3} , Yang Liu _{2,

6}

Affiliation

骨关节炎的进展与由滑膜巨噬细胞浸润和促炎性 M1 极化引起的慢性滑膜炎有关。因此，纳米制剂将巨噬细胞从 M1 表型复极化为 M2 表型被提议作为一种潜在的治疗策略。然而，由于药物从关节间隙的快速清除以及滑膜巨噬细胞对纳米颗粒的内吞效率低下，使用关节内注射药物实现足够的效果具有挑战性。在此，报道了凋亡软骨细胞膜包被的、负载槲皮素的金属有机骨架纳米颗粒作为治疗骨关节炎的免疫调节剂。含有各种天然“吃我”信号的凋亡软骨细胞膜伪装纳米粒子可以很容易地伪装成关节中的软骨细胞凋亡小体，因此更容易被滑膜巨噬细胞吞噬，类似于胞吐作用。此外，释放的槲皮素促进滑膜巨噬细胞极化为 M2 表型，并抑制关节软骨细胞的凋亡。体内结果表明，这种“特洛伊木马”策略可以延长纳米粒子在骨关节炎关节中的保留时间，提高治疗效果。总的来说，希望这项研究可以为工程化的细胞膜包被纳米颗粒提供一个潜在的通用平台，以通过模拟特定的炎症过程来解决炎症。释放的槲皮素促进滑膜巨噬细胞极化为 M2 表型，并抑制关节软骨细胞的凋亡。体内结果表明，这种“特洛伊木马”策略可以延长纳米粒子在骨关节炎关节中的保留时间，提高治疗效果。总的来说，希望这项研究可以为工程化的细胞膜包被纳米颗粒提供一个潜在的通用平台，以通过模拟特定的炎症过程来解决炎症。释放的槲皮素促进滑膜巨噬细胞极化为 M2 表型，并抑制关节软骨细胞的凋亡。体内结果表明，这种“特洛伊木马”策略可以延长纳米粒子在骨关节炎关节中的保留时间，提高治疗效果。总的来说，希望这项研究可以为工程化的细胞膜包被纳米颗粒提供一个潜在的通用平台，以通过模拟特定的炎症过程来解决炎症。

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Regulation of Synovial Macrophages Polarization by Mimicking Efferocytosis for Therapy of Osteoarthritis

The progression of osteoarthritis is associated with chronic synovitis caused by synovial macrophage infiltration and proinflammatory M1 polarization. Accordingly, repolarization of macrophages from the M1 to M2 phenotype by nanoagents is proposed as a potential treatment strategy. However, achieving adequate effects using intra-articular injected agents is challenging due to the rapid drug clearance from the joint space and poor efficiency of nanoparticles endocytosis by synovial macrophage cells. Herein, apoptotic chondrocyte membrane-coated, quercetin-loaded metal-organic framework nanoparticles as immunomodulators for treating osteoarthritis are reported. The apoptotic chondrocyte membrane-camouflaged nanoparticles containing various natural “eat me” signals can be easily disguised as chondrocyte apoptotic bodies in the joints, and thus are more easily phagocytized by synovial macrophages similarly to efferocytosis. Furthermore, the released quercetin promotes the polarization of synovial macrophages to the M2 phenotype and also inhibites the apoptosis of articular chondrocytes. In vivo results suggest that such a “Trojan horse” strategy can extend the retention time of nanoparticles in osteoarthritis joints and improve treatment efficacy. Collectively, it is hoped that this study can offer a potential and universal platform for engineered cell membrane-coated nanoparticles to resolve inflammation by simulating specific inflammatory processes.

更新日期：2022-10-09

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