Light-Programmable Nanocomposite Hydrogel for State-Switchable Wound Healing Promotion and Bacterial Infection Elimination,Advanced Healthcare Materials

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Light-Programmable Nanocomposite Hydrogel for State-Switchable Wound Healing Promotion and Bacterial Infection Elimination
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2022-10-08 , DOI: 10.1002/adhm.202201565
Zhekun Zhang ₁ , Juning Xie _{2,

3} , Jun Xing ₁ , Changhao Li ₁ , Tak Man Wong ₄ , Hui Yu ₃ , Yuanxing Li ₁ , Fabang Yang ₁ , Yu Tian ₅ , Huan Zhang ₁ , Wei Li ₁ , Chengyun Ning ₁ , Xiaolan Wang ₃ , Peng Yu ₁

Affiliation

Developing an ideal wound dressing that not only accelerates wound healing but also eliminates potential bacterial infections remains a difficult balancing act. This work reports the design of a light-programmable sodium alginate nanocomposite hydrogel loaded with BiOCl/polypyrrole (BOC/PPy) nanosheets for state-switchable wound healing promotion and bacterial infection elimination remotely. The nanocomposite hydrogel possesses programmable photoelectric or photothermal conversion due to the expanded light absorption range, optimized electron transmission interface, promoted photo-generated charge separation, and transfer of the BOC/PPy nanosheets. Under white light irradiation state, the nanocomposite hydrogel induces human umbilical vein endothelial cells migration and angiogenesis, and accelerates the healing efficiency of mouse skin in vivo. Under near-infrared light irradiation state, the nanocomposite hydrogel presents superior antibacterial capability in vitro, and reaches an antibacterial rate of 99.1% for Staphylococcus aureus infected skin wound in vivo. This light-programmable nanocomposite hydrogel provides an on-demand resolution of biological state-switching to balance wound healing and elimination of bacterial infection.

中文翻译：

用于状态可切换伤口愈合促进和细菌感染消除的光可编程纳米复合水凝胶

开发一种既能加速伤口愈合又能消除潜在细菌感染的理想伤口敷料仍然是一项艰难的平衡工作。这项工作报告了载有 BiOCl/聚吡咯 (BOC/PPy) 纳米片的光可编程海藻酸钠纳米复合水凝胶的设计，用于远程促进状态可切换的伤口愈合和消除细菌感染。由于扩大了光吸收范围、优化了电子传输界面、促进了光生电荷分离以及 BOC/PPy 纳米片的转移，纳米复合水凝胶具有可编程的光电或光热转换。在白光照射状态下，纳米复合水凝胶诱导人脐静脉内皮细胞迁移和血管生成，加速小鼠皮肤在体内的愈合效率。体内金黄色葡萄球菌感染的皮肤伤口。这种光可编程纳米复合水凝胶提供了生物状态转换的按需解决方案，以平衡伤口愈合和消除细菌感染。

更新日期：2022-10-08

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