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HY5-HDA9 orchestrates the transcription of HsfA2 to modulate salt stress response in Arabidopsis
Journal of Integrative Plant Biology ( IF 9.3 ) Pub Date : 2022-09-27 , DOI: 10.1111/jipb.13372 Jiaheng Yang 1 , Xiao Qu 1 , Tao Li 2 , Yixiang Gao 1 , Haonan Du 1 , Lanjie Zheng 1 , Manchun Ji 1 , Paifeng Zhang 1 , Yan Zhang 1 , Jinxin Hu 1 , Liangyu Liu 3 , Zefu Lu 4 , Zijian Yang 3 , Huiyong Zhang 2 , Jianping Yang 1 , Yongqing Jiao 1 , Xu Zheng 1
Journal of Integrative Plant Biology ( IF 9.3 ) Pub Date : 2022-09-27 , DOI: 10.1111/jipb.13372 Jiaheng Yang 1 , Xiao Qu 1 , Tao Li 2 , Yixiang Gao 1 , Haonan Du 1 , Lanjie Zheng 1 , Manchun Ji 1 , Paifeng Zhang 1 , Yan Zhang 1 , Jinxin Hu 1 , Liangyu Liu 3 , Zefu Lu 4 , Zijian Yang 3 , Huiyong Zhang 2 , Jianping Yang 1 , Yongqing Jiao 1 , Xu Zheng 1
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Integration of light signaling and diverse abiotic stress responses contribute to plant survival in a changing environment. Some reports have indicated that light signals contribute a plant's ability to deal with heat, cold, and stress. However, the molecular link between light signaling and the salt-response pathways remains unclear. We demonstrate here that increasing light intensity elevates the salt stress tolerance of plants. Depletion of HY5, a key component of light signaling, causes Arabidopsis thaliana to become salinity sensitive. Interestingly, the small heat shock protein (sHsp) family genes are upregulated in hy5-215 mutant plants, and HsfA2 is commonly involved in the regulation of these sHsps. We found that HY5 directly binds to the G-box motifs in the HsfA2 promoter, with the cooperation of HISTONE DEACETYLASE 9 (HDA9), to repress its expression. Furthermore, the accumulation of HDA9 and the interaction between HY5 and HDA9 are significantly enhanced by salt stress. On the contrary, high temperature triggers HY5 and HDA9 degradation, which leads to dissociation of HY5-HDA9 from the HsfA2 promoter, thereby reducing salt tolerance. Under salt and heat stress conditions, fine tuning of protein accumulation and an interaction between HY5 and HDA9 regulate HsfA2 expression. This implies that HY5, HDA9, and HsfA2 play important roles in the integration of light signaling with salt stress and heat shock response.
中文翻译：
HY5-HDA9 协调 HsfA2 的转录以调节拟南芥中的盐胁迫反应
光信号和多种非生物胁迫反应的整合有助于植物在不断变化的环境中生存。一些报告表明，光信号有助于植物应对热、冷和压力的能力。然而，光信号与盐反应途径之间的分子联系仍不清楚。我们在此证明，增加光照强度会提高植物的盐胁迫耐受性。HY5（光信号的关键组成部分）的耗尽导致拟南芥变得对盐度敏感。有趣的是，小热休克蛋白 (sHsp) 家族基因在hy5-215突变植物中上调，而 HsfA2 通常参与这些 sHsps 的调控。我们发现 HY5 直接与 G-box 基序结合HsfA2启动子，在组蛋白脱乙酰酶9（HDA9）的配合下，抑制其表达。此外，盐胁迫显着增强了 HDA9 的积累以及 HY5 和 HDA9 之间的相互作用。相反，高温触发 HY5 和 HDA9 降解，导致 HY5-HDA9 从HsfA2启动子上解离，从而降低耐盐性。在盐和热胁迫条件下，蛋白质积累的微调以及 HY5 和 HDA9 之间的相互作用调节HsfA2表达。这意味着HY5、HDA9和HsfA2在光信号与盐胁迫和热激反应的整合中发挥重要作用。
更新日期：2022-09-27
中文翻译：
HY5-HDA9 协调 HsfA2 的转录以调节拟南芥中的盐胁迫反应
光信号和多种非生物胁迫反应的整合有助于植物在不断变化的环境中生存。一些报告表明，光信号有助于植物应对热、冷和压力的能力。然而，光信号与盐反应途径之间的分子联系仍不清楚。我们在此证明，增加光照强度会提高植物的盐胁迫耐受性。HY5（光信号的关键组成部分）的耗尽导致拟南芥变得对盐度敏感。有趣的是，小热休克蛋白 (sHsp) 家族基因在hy5-215突变植物中上调，而 HsfA2 通常参与这些 sHsps 的调控。我们发现 HY5 直接与 G-box 基序结合HsfA2启动子，在组蛋白脱乙酰酶9（HDA9）的配合下，抑制其表达。此外，盐胁迫显着增强了 HDA9 的积累以及 HY5 和 HDA9 之间的相互作用。相反，高温触发 HY5 和 HDA9 降解，导致 HY5-HDA9 从HsfA2启动子上解离，从而降低耐盐性。在盐和热胁迫条件下，蛋白质积累的微调以及 HY5 和 HDA9 之间的相互作用调节HsfA2表达。这意味着HY5、HDA9和HsfA2在光信号与盐胁迫和热激反应的整合中发挥重要作用。
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