Engineering of Reversible NIR-II Redox-Responsive Fluorescent Probes for Imaging of Inflammation In Vivo,Angewandte Chemie International Edition

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Engineering of Reversible NIR-II Redox-Responsive Fluorescent Probes for Imaging of Inflammation In Vivo
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-09-23 , DOI: 10.1002/anie.202211409
Long He ₁ , Lin-Hui He ₁ , Shuai Xu ₁ , Tian-Bing Ren ₁ , Xing-Xing Zhang ₁ , Zuo-Jia Qin ₁ , Xiao-Bing Zhang ₁ , Lin Yuan ₁

Affiliation

We report a new class of trimethine skeleton NIR-II fluorophores (NIR-II Cy3s) with improved stability over traditional heptamethine NIR-II fluorophores and emission above 1000 nm. The NIR-II Cy3s can reversibly respond to HClO and reactive sulfur species (RSS) and can serve as an effective platform for the reversible monitoring of the HClO/RSS-mediated redox process in a pathophysiology environment. Finally, we applied NIR-II Cy3-988 to the reversible assessment of the redox environment and dynamic effect of drug treatment in an acute inflammation model and of redox potential changes during liver injury and repair.

中文翻译：

用于体内炎症成像的可逆 NIR-II 氧化还原响应荧光探针的工程

我们报告了一类新的三亚甲基骨架 NIR-II 荧光团 (NIR-II Cy3s)，其稳定性优于传统的七亚甲基 NIR-II 荧光团，发射波长高于 1000 nm。NIR-II Cy3s 可以可逆地响应 HClO 和活性硫物质 (RSS)，并且可以作为在病理生理学环境中可逆监测 HClO/RSS 介导的氧化还原过程的有效平台。最后，我们将 NIR-II Cy3-988 应用于急性炎症模型中药物治疗的氧化还原环境和动态效应的可逆评估，以及肝损伤和修复过程中氧化还原电位的变化。

更新日期：2022-09-23

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