鲁米诺电化学发光系统信号放大的电催化和自富集策略,Analytical Chemistry

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鲁米诺电化学发光系统信号放大的电催化和自富集策略
Analytical Chemistry ( IF 6.7 ) Pub Date : 2022-09-16 , DOI: 10.1021/acs.analchem.2c02699
Zhongyan Xu ₁ , Zhihui Guo ₁ , Xingwang Zheng ₁

Affiliation

由于鲁米诺的低量子产率，已经开发了许多策略来提高鲁米诺电化学发光 (ECL) 系统的强度。值得注意的是，进行了大量研究来提高鲁米诺 ECL 强度，这依赖于增加活性氧 (ROS) 的浓度。这里，一个 Co-N _x在碳纳米管表面原位制备用硝酸或盐酸处理的-C电催化剂（分别命名为Co-POC-O或Co-POC-R）。令人惊讶的是，与Co-POC-R相比，Co-POC-O电催化剂不仅表现出优异的氧还原反应（ORR）性能，而且通过非共价键而不是共价键和物理混合来富集鲁米诺。该方法提高了参与电化学反应的鲁米诺量，缩短了氧化鲁米诺与 ROS 之间的电子转移距离，显着提高了 ECL 强度（比裸电极高 10 倍，比裸电极高 2 倍） Co-POC-R)。该平台实现了高灵敏度的多巴胺 (DA)，检测限为 1.0 pM，线性范围为 10 pM 至 1.0 nM。在这项工作中，

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An Electrocatalysis and Self-Enrichment Strategy for Signal Amplification of Luminol Electrochemiluminescence Systems

Numerous strategies have been developed to improve the intensity of a luminol electrochemiluminescence (ECL) system due to the low quantum yield of luminol. Notably, considerable research was carried out to improve luminol ECL intensity relying on increasing the concentration of reactive oxygen species (ROS). Herein, a Co–N_x–C electrocatalyst treated with nitric acid or hydrochloric acid (named as Co-POC-O or Co-POC-R, respectively) was in situ prepared on the surface of carbon nanotubes. Surprisingly, compared with Co-POC-R, the Co-POC-O electrocatalyst not only displays excellent oxygen reduction reaction (ORR) performance but also enriches luminol via non-covalent bonds rather than covalent bonds and physical mixing. This method improves the amount of luminol involved in the electrochemical reaction as well as shortens the distance for electron transfer between oxidized luminol and ROS, which significantly enhances the ECL intensity (10-fold higher than that of the bare electrode and 2-fold higher than that of Co-POC-R). The platform realizes highly sensitive dopamine (DA) with a detection limit of 1.0 pM and a linear range from 10 pM to 1.0 nM. In this work, Co-POC-O is both the co-reaction accelerator and carrier material of luminophore species, which provides a new idea to realize ECL signal amplification.

更新日期：2022-09-16

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