Skin is the largest organ in human body, and it plays an important role in regulating physiological microenvironments and acts as a barrier to protect human body from harmful intrusions. The demand for fully functional skin models (also called skin equivalents, SE) in an in-vivo mimicking culturing microenvironment has been increased dramatically due to the fast development in skin disease treatments and skin care products. Owing to the emerging of the concept and technology of organ-on-chips along with the three-dimensional (3D) bioprinting technology, 3D skin models and their applications have been fast evolving. In this paper, the advances in the development of 3D skin models along with skin-on-a-chip (SOC) are reviewed and commented. One of the findings with this paper is that the SOC together with the 3D bioprinting technology is promising to construct fully functional 3D skin models in the field of pharmaceutical and cosmetic industries.

皮肤是人体最大的器官，对调节生理微环境起着重要作用，是保护人体免受有害入侵的屏障。对体内全功能皮肤模型（也称为皮肤等效物，SE）的需求由于皮肤病治疗和护肤品的快速发展，模拟培养微环境的数量急剧增加。由于器官芯片的概念和技术以及三维（3D）生物打印技术的出现，3D 皮肤模型及其应用得到了快速发展。在本文中，回顾和评论了 3D 皮肤模型以及片上皮肤 (SOC) 的发展进展。这篇论文的发现之一是 SOC 与 3D 生物打印技术一起有望在制药和化妆品行业构建功能齐全的 3D 皮肤模型。