Localization-dictated function for METTL3,Nature Cell Biology

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Localization-dictated function for METTL3
Nature Cell Biology ( IF 17.3 ) Pub Date : 2022-08-04 , DOI: 10.1038/s41556-022-00972-2
Sylvain Delaunay ₁ , Michaela Frye ₁

Affiliation

Aberrant subcellular localization of proteins contributes to the pathogenesis of cancer. A study now reports that the mis-localization of METTL3, a nuclear N6-adenosine methyltransferase, to the cytoplasm promotes gastric cancer by enhancing mRNA translation of a subset of oncogenes, independently of the N6-methyladenosine (m6A) modification.

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