Diastereodivergent Aldol-Type Coupling of Alkoxyallenes with Pentafluorophenyl Esters Enabled by Synergistic Palladium/Chiral Lewis Base Catalysis,Angewandte Chemie International Edition

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Diastereodivergent Aldol-Type Coupling of Alkoxyallenes with Pentafluorophenyl Esters Enabled by Synergistic Palladium/Chiral Lewis Base Catalysis
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-06-17 , DOI: 10.1002/anie.202207621
Minghui Zhu ₁ , Peixin Wang ₁ , Qinglong Zhang ₁ , Wenjun Tang ₂ , Weiwei Zi _{1,

3}

Affiliation

A synergistic combination of a chiral palladium catalyst and a chiral Lewis base catalyst was used to achieve diastereodivergent aldol-type coupling reactions of alkoxyallenes with pentafluorophenyl esters. Each of the four stereoisomers of the coupling products could be selectively prepared from the same pair of substrates simply by using an appropriate pair of chiral catalysts. DFT calculations were performed to rationalize the stereochemistry of this reaction.

中文翻译：

通过协同钯/手性路易斯碱催化实现烷氧基丙二烯与五氟苯基酯的非对映异构醛醇型偶联

手性钯催化剂和手性路易斯碱催化剂的协同组合用于实现烷氧基丙二烯与五氟苯酯的非对映异构醛醇型偶联反应。偶联产物的四种立体异构体中的每一种都可以通过使用适当的手性催化剂对从同一对底物选择性地制备。进行 DFT 计算以合理化该反应的立体化学。

更新日期：2022-06-17

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