Umpolung AlaB Reagents for the Synthesis of Non-Proteogenic Amino Acids, Peptides and Proteins**,Angewandte Chemie International Edition

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Umpolung AlaB Reagents for the Synthesis of Non-Proteogenic Amino Acids, Peptides and Proteins**
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-06-02 , DOI: 10.1002/anie.202207153
Feng Zhu ₁ , Eric Miller ₂ , Wyatt C Powell ₂ , Kelly Johnson ₂ , Alexander Beggs ₂ , Garrett E Evenson ₂ , Maciej A Walczak ₂

Affiliation

A novel amino acid synthon in the form of boronoalanine (Ala^B) suitable for umpolung peptide/protein functionalization is described. It is demonstrated that Ala^B can be incorporated into peptides and proteins, and remains stable under solid-phase synthesis, native chemical ligation, and radical desulfurization. Furthermore, Ala^B is a competent partner in inter(intra)molecular C(sp³)−C(sp²) cross-couplings.

中文翻译：

用于合成非蛋白氨基酸、肽和蛋白质的 Umpolung AlaB 试剂**

描述了一种适用于 umpolung 肽/蛋白质功能化的硼丙氨酸 (Ala ^B )形式的新型氨基酸合成子。结果表明，Ala ^B可以掺入肽和蛋白质中，并且在固相合成、天然化学连接和自由基脱硫下保持稳定。此外，Ala ^B是分子间（内）C( sp ³ )−C( sp ² ) 交叉偶联的有效伙伴。

更新日期：2022-06-02

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