Fibrin Sealants: Challenges and Solutions,ACS Biomaterials Science & Engineering

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Fibrin Sealants: Challenges and Solutions
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2022-05-24 , DOI: 10.1021/acsbiomaterials.1c01437
Matthias Beudert ₁ , Marcus Gutmann ₁ , Tessa Lühmann ₁ , Lorenz Meinel _{1,

2}

Affiliation

Intraoperative bleeding and postoperative bleeding are major surgical complications. Tissue sealants, hemostats, and adhesives provide the armamentarium for establishing hemostatic balance, including the tissue sealant fibrin. Fibrin sealants combine advantages including instantaneous effect, biocompatibility, and biodegradability. However, several challenges remain. This review summarizes current fibrin product generations and highlights new trends and potential strategies for future improvement.

中文翻译：

纤维蛋白密封剂：挑战和解决方案

术中出血和术后出血是主要的手术并发症。组织密封剂、止血剂和粘合剂为建立止血平衡提供了设备，包括组织密封剂纤维蛋白。纤维蛋白密封剂结合了瞬时效果、生物相容性和生物降解性等优点。然而，仍然存在一些挑战。这篇综述总结了当前的纤维蛋白产品世代，并强调了未来改进的新趋势和潜在策略。

更新日期：2022-05-24

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