Subcellular distribution, localization, and function of noncoding RNAs,WIREs RNA

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Subcellular distribution, localization, and function of noncoding RNAs
WIREs RNA ( IF 6.4 ) Pub Date : 2022-04-12 , DOI: 10.1002/wrna.1729
Lingjie Sang _{1,

2,

3} , Luojia Yang _{1,

2,

3} , Qiwei Ge _{2,

3,

4} , Shanshan Xie _{2,

4,

5} , Tianhua Zhou _{2,

4,

5} , Aifu Lin _{1,

2,

3,

6}

Affiliation

Eukaryotic cells contain subcellular organelles with spatiotemporal regulation to coordinate various biochemical reactions. The various organelles perform their essential biological functions by employing specific biomolecules, including nucleic acids. Recent studies have revealed that noncoding RNAs (ncRNAs) are highly compartmentalized in cells and that their spatial distribution is intimately related to their functions. Dysregulation of subcellular ncRNAs can disrupt cellular homeostasis and cause human diseases. Mitochondria are responsible for energy generation to fuel cell growth and proliferation. Therefore, identifying mitochondria-associated ncRNAs helps to reveal new regulatory mechanisms and physiological functions of mitochondria. In this review, we summarize the latest advances in subcellular ncRNAs derived from either the nuclear or mitochondrial genome. We also discuss available biological approaches for investigating organelle-specific ncRNAs. Exploring the distribution and function of subcellular ncRNAs may facilitate the understanding of endomembrane dynamics and provide potential strategies for clinical transformation.

中文翻译：

非编码 RNA 的亚细胞分布、定位和功能

真核细胞包含具有时空调节功能的亚细胞器，以协调各种生化反应。各种细胞器通过使用特定的生物分子（包括核酸）来执行其基本的生物学功能。最近的研究表明，非编码 RNA (ncRNA) 在细胞中高度区室化，它们的空间分布与其功能密切相关。亚细胞 ncRNA 的失调会破坏细胞稳态并导致人类疾病。线粒体负责产生能量以促进细胞生长和增殖。因此，鉴定线粒体相关的ncRNA有助于揭示线粒体新的调控机制和生理功能。在这篇评论中，我们总结了源自核或线粒体基因组的亚细胞 ncRNA 的最新进展。我们还讨论了用于研究细胞器特异性 ncRNA 的可用生物学方法。探索亚细胞 ncRNA 的分布和功能可能有助于理解内膜动力学，并为临床转化提供潜在策略。

更新日期：2022-04-12

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