Wound Microenvironment-Responsive Protein Hydrogel Drug-Loaded System with Accelerating Healing and Antibacterial Property,ACS Applied Materials & Interfaces

当前位置： X-MOL 学术 › ACS Appl. Mater. Interfaces › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Wound Microenvironment-Responsive Protein Hydrogel Drug-Loaded System with Accelerating Healing and Antibacterial Property
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2022-02-17 , DOI: 10.1021/acsami.2c00373
Rong Zhang ₁ , Yongchang Tian ₁ , Long Pang ₁ , Taimin Xu ₁ , Bing Yu _{1,

2} , Hailin Cong _{1,

2} , Youqing Shen _{1,

3}

Affiliation

Growth factors play a vital role in wound healing, and novel hydrogel carriers suitable for growth factors have always been a research hotspot in the wound healthcare field. In this work, a wound microenvironment-responsive hydrogel drug-loading system was constructed by cross-linking of the internal electron-deficient polyester and bovine serum albumin (BSA) via catalyst-free amino-yne bioconjugation. The slightly acidic microenvironment of wound tissues induces the charge removal of BSA chains, thus releasing the basic fibroblast growth factor (bFGF) loaded through electrostatic action. Besides, the BSA chains in the gel network further endow their excellent biocompatibility and biodegradability, also making them more suitable for bFGF loading. The wound caring evaluation of the hydrogel in the full-thickness skin wound indicated that the protein-based hydrogel significantly promotes the proliferation and differentiation of fibroblasts, collagen accumulation, and epidermal layer stacking, thus significantly shortening the healing process. This strategy paved the way for broadening the application of the growth factors in the wound care field.

中文翻译：

具有加速愈合和抗菌性能的伤口微环境响应蛋白水凝胶载药系统

生长因子在伤口愈合中起着至关重要的作用，适合生长因子的新型水凝胶载体一直是伤口保健领域的研究热点。在这项工作中，通过无催化剂氨基炔生物缀合的内部缺电子聚酯和牛血清白蛋白（BSA）的交联，构建了一个伤口微环境响应的水凝胶载药系统。伤口组织的微酸性微环境诱导BSA链的电荷去除，从而释放通过静电作用加载的碱性成纤维细胞生长因子（bFGF）。此外，凝胶网络中的 BSA 链进一步赋予其优异的生物相容性和生物降解性，也使其更适合负载 bFGF。水凝胶在全层皮肤伤口中的伤口护理评价表明，基于蛋白质的水凝胶显着促进成纤维细胞的增殖和分化、胶原蛋白的积累和表皮层的堆积，从而显着缩短愈合过程。这一策略为扩大生长因子在伤口护理领域的应用铺平了道路。

更新日期：2022-02-17

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11