CuCl2·2H2O/TBHP mediated synthesis of β-enaminones via coupling reaction of vinyl azides with aldehydes,Organic & Biomolecular Chemistry

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CuCl2·2H2O/TBHP mediated synthesis of β-enaminones via coupling reaction of vinyl azides with aldehydes
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2022-02-07 , DOI: 10.1039/d1ob02479e
Yaohong Zhang ₁ , Mengqiang Luo _{1,

2} , Yichan Zhang ₃ , Kai Cheng ₁ , Yong Li ₁ , Chenze Qi ₁ , Runpu Shen ₂ , Hai Wang ₁

Affiliation

A facile and efficient oxidative functionalization of vinyl azides with aldehydes furnishing a diverse array of β-acylated enaminones was developed. The cross coupling was accomplished in the presence of CuCl₂·2H₂O/TBHP and produced the desired β-acylated enaminones in a (Z)-stereo-selective and atom-economic manner, which make this protocol particularly attractive. In the transformation, the new C–C and C–N bonds were formed via a one-pot strategy including the process of radical addition and recombination.

中文翻译：

CuCl2·2H2O/TBHP介导的乙烯基叠氮化物与醛的偶联反应合成β-烯胺酮

开发了一种简便有效的乙烯基叠氮化物与醛的氧化官能化，提供了多种 β-酰化烯胺酮。交叉偶联是在 CuCl ₂ ·2H ₂ O/TBHP 存在下完成的，并以 ( Z )-立体选择性和原子经济的方式产生所需的 β-酰化烯胺酮，这使得该协议特别有吸引力。在转化过程中，新的 C-C 和 C-N 键是通过一锅法形成的，包括自由基加成和重组过程。

更新日期：2022-02-07

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