Antimicrobial Peptides and Macromolecules for Combating Microbial Infections: From Agents to Interfaces,ACS Applied Bio Materials

当前位置： X-MOL 学术 › ACS Appl. Bio Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Antimicrobial Peptides and Macromolecules for Combating Microbial Infections: From Agents to Interfaces
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2022-01-24 , DOI: 10.1021/acsabm.1c01132
Luofeng Yu ₁ , Kunpeng Li ₁ , Jing Zhang ₁ , Haoyu Jin ₁ , Atif Saleem ₁ , Qing Song ₁ , Qingyan Jia ₁ , Peng Li ₁

Affiliation

Bacterial resistance caused by the overuse of antibiotics and the shelter of biofilms has evolved into a global health crisis, which drives researchers to continuously explore antimicrobial molecules and strategies to fight against drug-resistant bacteria and biofilm-associated infections. Cationic antimicrobial peptides (AMPs) are considered to be a category of potential alternative for antibiotics owing to their excellent bactericidal potency and lesser likelihood of inducing drug resistance through their distinctive antimicrobial mechanisms. In this review, the hitherto reported plentiful action modes of AMPs are systematically classified into 15 types and three categories (membrane destructive, nondestructive membrane disturbance, and intracellular targeting mechanisms). Besides natural AMPs, cationic polypeptides, synthetic polymers, and biopolymers enable to achieve tunable antimicrobial properties by optimizing their structures. Subsequently, the applications of these cationic antimicrobial agents at the biointerface as contact-active surface coatings and multifunctional wound dressings are also emphasized here. At last, we provide our perspectives on the development of clinically significant cationic antimicrobials and related challenges in the translation of these materials.

中文翻译：

抗微生物感染的抗菌肽和大分子：从试剂到界面

过度使用抗生素和生物膜庇护所导致的细菌耐药性已演变为全球健康危机，这促使研究人员不断探索抗菌分子和策略，以对抗耐药细菌和生物膜相关感染。阳离子抗菌肽 (AMPs) 被认为是一类潜在的抗生素替代品，因为它们具有出色的杀菌效力，并且通过其独特的抗菌机制诱导耐药性的可能性较小。在这篇综述中，迄今为止报道的丰富的 AMP 作用模式系统地分为 15 种类型和 3 类（膜破坏性、非破坏性膜干扰和细胞内靶向机制）。除了天然 AMP、阳离子多肽、合成聚合物、和生物聚合物能够通过优化其结构来实现可调的抗菌性能。随后，这里还强调了这些阳离子抗菌剂在生物界面上作为接触活性表面涂层和多功能伤口敷料的应用。最后，我们就具有临床意义的阳离子抗菌剂的开发以及这些材料转化过程中的相关挑战提供了我们的观点。

更新日期：2022-01-24

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南