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Mitogen-activated protein kinase cascades in plant signaling
Journal of Integrative Plant Biology ( IF 9.3 ) Pub Date : 2022-01-05 , DOI: 10.1111/jipb.13215 Mengmeng Zhang 1 , Shuqun Zhang 2
Journal of Integrative Plant Biology ( IF 9.3 ) Pub Date : 2022-01-05 , DOI: 10.1111/jipb.13215 Mengmeng Zhang 1 , Shuqun Zhang 2
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Mitogen-activated protein kinase (MAPK) cascades are key signaling modules downstream of receptors/sensors that perceive either endogenously produced stimuli such as peptide ligands and damage-associated molecular patterns (DAMPs) or exogenously originated stimuli such as pathogen/microbe-associated molecular patterns (P/MAMPs), pathogen-derived effectors, and environmental factors. In this review, we provide a historic view of plant MAPK research and summarize recent advances in the establishment of MAPK cascades as essential components in plant immunity, response to environmental stresses, and normal growth and development. Each tier of the MAPK cascades is encoded by a small gene family, and multiple members can function redundantly in an MAPK cascade. Yet, they carry out a diverse array of biological functions in plants. How the signaling specificity is achieved has become an interesting topic of MAPK research. Future investigations into the molecular mechanism(s) underlying the regulation of MAPK activation including the activation kinetics and magnitude in response to a stimulus, the spatiotemporal expression patterns of all the components in the signaling pathway, and functional characterization of novel MAPK substrates are central to our understanding of MAPK functions and signaling specificity in plants.
中文翻译：
植物信号中的丝裂原活化蛋白激酶级联
丝裂原活化蛋白激酶 (MAPK) 级联是受体/传感器下游的关键信号模块，可感知内源性刺激，如肽配体和损伤相关分子模式 (DAMP)，或外源性刺激，如病原体/微生物相关分子模式(P/MAMPs)、病原体衍生的效应器和环境因素。在这篇综述中，我们提供了植物 MAPK 研究的历史观点，并总结了建立 MAPK 级联作为植物免疫、环境胁迫响应和正常生长发育的重要组成部分的最新进展。MAPK 级联的每一层都由一个小基因家族编码，多个成员可以在 MAPK 级联中冗余地发挥作用。然而，它们在植物中发挥着多种生物功能。如何实现信号特异性已成为 MAPK 研究的一个有趣课题。未来对 MAPK 激活调控的分子机制的研究，包括对刺激的激活动力学和幅度、信号通路中所有成分的时空表达模式以及新型 MAPK 底物的功能表征，这些都是我们对植物中 MAPK 功能和信号特异性的理解。
更新日期：2022-01-05
中文翻译：
植物信号中的丝裂原活化蛋白激酶级联
丝裂原活化蛋白激酶 (MAPK) 级联是受体/传感器下游的关键信号模块，可感知内源性刺激，如肽配体和损伤相关分子模式 (DAMP)，或外源性刺激，如病原体/微生物相关分子模式(P/MAMPs)、病原体衍生的效应器和环境因素。在这篇综述中，我们提供了植物 MAPK 研究的历史观点，并总结了建立 MAPK 级联作为植物免疫、环境胁迫响应和正常生长发育的重要组成部分的最新进展。MAPK 级联的每一层都由一个小基因家族编码，多个成员可以在 MAPK 级联中冗余地发挥作用。然而，它们在植物中发挥着多种生物功能。如何实现信号特异性已成为 MAPK 研究的一个有趣课题。未来对 MAPK 激活调控的分子机制的研究，包括对刺激的激活动力学和幅度、信号通路中所有成分的时空表达模式以及新型 MAPK 底物的功能表征，这些都是我们对植物中 MAPK 功能和信号特异性的理解。
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