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Acute normobaric hypoxia blunts contraction-mediated mTORC1- and JNK-signaling in human skeletal muscle
Acta Physiologica ( IF 5.6 ) Pub Date : 2022-01-05 , DOI: 10.1111/apha.13771 Marcus Moberg 1, 2 , William Apró 1, 3 , Oscar Horwath 1 , Gerrit van Hall 4, 5 , Sarah Joan Blackwood 1 , Abram Katz 1
Acta Physiologica ( IF 5.6 ) Pub Date : 2022-01-05 , DOI: 10.1111/apha.13771 Marcus Moberg 1, 2 , William Apró 1, 3 , Oscar Horwath 1 , Gerrit van Hall 4, 5 , Sarah Joan Blackwood 1 , Abram Katz 1
Affiliation
Hypoxia has been shown to reduce resistance exercise-induced stimulation of protein synthesis and long-term gains in muscle mass. However, the mechanism whereby hypoxia exerts its effect is not clear. Here, we examine the effect of acute hypoxia on the activity of several signalling pathways involved in the regulation of muscle growth following a bout of resistance exercise.
中文翻译:
急性常压缺氧会减弱人体骨骼肌中收缩介导的 mTORC1 和 JNK 信号传导
低氧已被证明可以减少抵抗运动引起的蛋白质合成刺激和肌肉质量的长期增加。然而,缺氧发挥其作用的机制尚不清楚。在这里,我们检查了急性缺氧对几条参与抗阻运动后肌肉生长调节的信号通路活性的影响。
更新日期:2022-01-20
中文翻译:
急性常压缺氧会减弱人体骨骼肌中收缩介导的 mTORC1 和 JNK 信号传导
低氧已被证明可以减少抵抗运动引起的蛋白质合成刺激和肌肉质量的长期增加。然而,缺氧发挥其作用的机制尚不清楚。在这里,我们检查了急性缺氧对几条参与抗阻运动后肌肉生长调节的信号通路活性的影响。