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H2O2-mediated room temperature synthesis of 2-arylacetophenones from arylhydrazines and vinyl azides in water
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2021-12-22 , DOI: 10.1039/d1ob02023d Mengqiang Luo 1, 2 , Yaohong Zhang 1 , Ping Fang 1 , Yan Li 1 , Chenze Qi 1 , Yong Li 1 , Runpu Shen 2 , Kai Cheng 1 , Hai Wang 1
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2021-12-22 , DOI: 10.1039/d1ob02023d Mengqiang Luo 1, 2 , Yaohong Zhang 1 , Ping Fang 1 , Yan Li 1 , Chenze Qi 1 , Yong Li 1 , Runpu Shen 2 , Kai Cheng 1 , Hai Wang 1
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An environmentally benign, cost-efficient and practical methodology for the room temperature synthesis of 2-arylacetophenones in water has been discovered. The facile and efficient transformation involves the oxidative radical addition of arylhydrazines with α-aryl vinyl azides in the presence of H2O2 (as a radical initiator) and PEG-800 (as a phase-transfer catalyst). From the viewpoint of green chemistry and organic synthesis, the present protocol is of great significance because of using cheap, non-toxic and readily available starting materials and reagents as well as amenability to gram-scale synthesis, which provides an attractive strategy to access 2-arylacetophenones.
中文翻译：
H2O2 介导的芳基肼和乙烯基叠氮化物在水中室温合成 2-芳基苯乙酮
已经发现了一种用于在水中室温合成 2-芳基苯乙酮的环境友好、经济高效且实用的方法。简便有效的转化涉及芳基肼与 α-芳基乙烯基叠氮化物在 H 2 O 2（作为自由基引发剂）和 PEG-800（作为相转移催化剂）存在下的氧化自由基加成。从绿色化学和有机合成的角度来看，本协议具有重要意义，因为它使用了廉价、无毒且易于获得的起始材料和试剂，并且易于进行克级合成，这为获取 2 提供了有吸引力的策略-芳基苯乙酮。
更新日期：2021-12-23
中文翻译：
H2O2 介导的芳基肼和乙烯基叠氮化物在水中室温合成 2-芳基苯乙酮
已经发现了一种用于在水中室温合成 2-芳基苯乙酮的环境友好、经济高效且实用的方法。简便有效的转化涉及芳基肼与 α-芳基乙烯基叠氮化物在 H 2 O 2（作为自由基引发剂）和 PEG-800（作为相转移催化剂）存在下的氧化自由基加成。从绿色化学和有机合成的角度来看，本协议具有重要意义，因为它使用了廉价、无毒且易于获得的起始材料和试剂，并且易于进行克级合成，这为获取 2 提供了有吸引力的策略-芳基苯乙酮。
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