Alkoxycarbonyl radicals from alkyloxalyl chlorides: photoinduced synthesis of isoquinolinediones under visible light irradiation,Organic Chemistry Frontiers

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Alkoxycarbonyl radicals from alkyloxalyl chlorides: photoinduced synthesis of isoquinolinediones under visible light irradiation
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2021-10-22 , DOI: 10.1039/d1qo01368h
Mingjuan Ji ₁ , Liang Xu ₁ , Xiangxiang Luo ₁ , Minghui Jiang ₁ , Siyu Wang ₁ , Jian-Qiang Chen ₁ , Jie Wu _{1,

2,

3}

Affiliation

Alkyloxalyl chlorides, generated from alcohols and oxalyl chlorides, are used as alkoxycarbonyl radicals in the reaction of N-acryloyl benzamides under photocatalysis at room temperature. In this report, we demonstrate that this approach can be compatible with a variety of alcohol-containing pharmaceutically active compounds under visible light irradiation. A variety of isoquinoline-1,3(2H,4H)-diones are prepared in moderate to good yields.

中文翻译：

来自烷基草酰氯的烷氧基羰基：在可见光照射下光诱导合成异喹啉二酮

由醇和草酰氯生成的烷氧基羰基在室温光催化下用作N-丙烯酰苯甲酰胺反应中的烷氧基羰基。在这份报告中，我们证明了这种方法可以在可见光照射下与各种含酒精的药物活性化合物兼容。各种异喹啉-1,3(2 H ,4 H )-二酮以中等至良好的产率制备。

更新日期：2021-10-29

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