Background: Cissus incisa is a Vitaceae with a pantropical distribution. In northern Mexico, its leaves have traditionally been used to treat skin infections, abscesses and tumors. Despite its medicinal uses, few studies have been reported.

Objective: The objective of this study is to summarize the phytochemical and biological studies carried out so far on the leaves of C. incisa, since this part of the plant is the one frequently used, and awaken scientific interest towards the plant.

Methods: Since C. incisa was an undocumented species, most of the information comes from reports of our research group. Databases, books, and websites were also consulted. The information collected was organized and presented in a synthesized way. Plant name was checked with the database “The Plant List”.

Results: 171, 260, and 114 metabolites were identified by UHPLC-QFTOF-MS in the hexane, chloroform/ methanol, and aqueous extracts, respectively. Fatty acyls, sphingolipids, sterols, glycerolipids, prenol lipids, and terpenes are common metabolites found in these extracts. 2-(2´-hydroxydecanoyl amino)-1,3,4-hexadecanotriol-8-ene, 2,3-dihydroxypropyl tetracosanoate, β-sitosterol, β-sitosterol-D-glucopyranoside, α-amyrin-3-O-β-D-glucopyranoside were also isolated and characterized. Extracts, phytocompounds and semi-synthetic derivatives showed antimicrobial activity against multi-drug resistant bacteria and various cancer cell lines. Results from Perturbation- Theory-Machine Learning-Information-Fusion model (PTMLIF), molecular docking, and vesicular contents assay identified potential targets on the cell membrane, suggesting an antibacterial mechanism of action for ceramides from C. incisa leaves.

Conclusion: This review reports the efforts of the scientific community in authenticating species used in traditional medicine. Moreover, it gives a compendium of phytochemistry and the biological activities of the components from C. incisa leaves.

背景： Cissus incisa 是一种泛热带分布的葡萄科植物。在墨西哥北部，它的叶子传统上被用来治疗皮肤感染、脓肿和肿瘤。尽管有药用价值，但很少有研究报道。

目的：本研究的目的是总结迄今为止对 C. incisa 叶子进行的植物化学和生物学研究，因为这部分植物是常用的植物，并唤起对植物的科学兴趣。

方法：由于 C. incisa 是一个未记录的物种，大部分信息来自我们研究小组的报告。还查阅了数据库、书籍和网站。收集的信息以综合方式组织和呈现。植物名称与数据库“植物清单”核对。

结果：通过 UHPLC-QFTOF-MS 在己烷、氯仿/甲醇和水提取物中分别鉴定出 171、260 和 114 种代谢物。脂肪酰基、鞘脂、甾醇、甘油脂、异戊烯醇脂和萜烯是在这些提取物中发现的常见代谢物。2-(2´-羟基癸酰氨基)-1,3,4-hexadecanotriol-8-ene, 2,3-dihydroxypropyl tetracosanoate, β-谷甾醇, β-谷甾醇-D-吡喃葡萄糖苷, α-amyrin-3-O-β -D-吡喃葡萄糖苷也被分离和表征。提取物、植物化合物和半合成衍生物对多重耐药细菌和各种癌细胞系显示出抗菌活性。扰动理论机器学习信息融合模型 (PTMLIF)、分子对接和囊泡内容物分析的结果确定了细胞膜上的潜在目标，

结论：本综述报告了科学界在鉴定用于传统医学的物种方面所做的努力。此外，它还提供了植物化学概要和 C. incisa 叶中成分的生物活性。