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Small Molecule-Capped Gold Nanoclusters for Curing Skin Infections
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-07-21 , DOI: 10.1021/acsami.1c04944 Yangzhouyun Xie 1 , Qiang Zhang 2 , Wenfu Zheng 2 , Xingyu Jiang 1
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-07-21 , DOI: 10.1021/acsami.1c04944 Yangzhouyun Xie 1 , Qiang Zhang 2 , Wenfu Zheng 2 , Xingyu Jiang 1
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With the long-term and extensive abuse of antibiotics, bacteria can mutate into multidrug-resistant (MDR) strains, resist the existing antibiotics, and escape the danger of being killed. MDR bacteria-caused skin infections are intractable and chronic, becoming one of the most significant and global public-health issues. Thus, the development of novel antimicrobial materials is urgently needed. Non-antibiotic small molecule-modified gold nanoclusters (AuNCs) have great potential as a substitute for commercial antibiotics. Still, their narrow antibacterial spectrum hinders their wide clinical applications. Herein, we report that 4,6-diamino-2-pyrimidinethiol (DAPT)-modified AuNCs (DAPT-AuNCs) can fight against Gram-negative and Gram-positive bacterial strains as well as their MDR counterparts. By modifying DAPT-AuNCs on nanofibrous films, we develop an antibiotic film as innovative dressings for curing incised wounds, which exhibits excellent therapeutic effects on wounds infected by MDR bacteria. Compared to the narrow-spectral one, the broad-spectral antibacterial activity of the DAPT-AuNCs-modified film is more suitable for preventing and treating skin infections caused by various kinds of unknown bacteria. Moreover, the antibacterial films display excellent biocompatibility, implying the great potential for clinical applications.
中文翻译：
用于治疗皮肤感染的小分子覆盖金纳米簇
随着抗生素的长期、广泛滥用，细菌可以变异为多重耐药（MDR）菌株，对现有的抗生素产生抵抗力，从而逃脱被杀死的危险。耐多药细菌引起的皮肤感染是顽固且慢性的，已成为最重要的全球公共卫生问题之一。因此，迫切需要开发新型抗菌材料。非抗生素小分子修饰金纳米簇（AuNC）作为商业抗生素的替代品具有巨大潜力。尽管如此，它们的抗菌谱较窄阻碍了其广泛的临床应用。在此，我们报告4,6-二氨基-2-嘧啶硫醇（DAPT）修饰的AuNC（DAPT-AuNC）可以对抗革兰氏阴性和革兰氏阳性细菌菌株及其MDR对应物。通过在纳米纤维膜上修饰 DAPT-AuNC，我们开发了一种抗生素膜作为治疗切开伤口的创新敷料，对 MDR 细菌感染的伤口表现出优异的治疗效果。与窄谱抗菌谱相比，DAPT-AuNCs修饰膜的广谱抗菌活性更适合预防和治疗各种未知细菌引起的皮肤感染。此外，抗菌薄膜具有良好的生物相容性，具有巨大的临床应用潜力。
更新日期：2021-08-04
中文翻译：
用于治疗皮肤感染的小分子覆盖金纳米簇
随着抗生素的长期、广泛滥用，细菌可以变异为多重耐药（MDR）菌株，对现有的抗生素产生抵抗力，从而逃脱被杀死的危险。耐多药细菌引起的皮肤感染是顽固且慢性的，已成为最重要的全球公共卫生问题之一。因此，迫切需要开发新型抗菌材料。非抗生素小分子修饰金纳米簇（AuNC）作为商业抗生素的替代品具有巨大潜力。尽管如此，它们的抗菌谱较窄阻碍了其广泛的临床应用。在此，我们报告4,6-二氨基-2-嘧啶硫醇（DAPT）修饰的AuNC（DAPT-AuNC）可以对抗革兰氏阴性和革兰氏阳性细菌菌株及其MDR对应物。通过在纳米纤维膜上修饰 DAPT-AuNC，我们开发了一种抗生素膜作为治疗切开伤口的创新敷料，对 MDR 细菌感染的伤口表现出优异的治疗效果。与窄谱抗菌谱相比，DAPT-AuNCs修饰膜的广谱抗菌活性更适合预防和治疗各种未知细菌引起的皮肤感染。此外，抗菌薄膜具有良好的生物相容性，具有巨大的临床应用潜力。
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