Current Topics in Medicinal Chemistry ( IF 2.9 ) Pub Date : 2021-10-31 , DOI: 10.2174/1568026621666210527103225 Fanjie Hu 1 , Lina Zhang 1 , Kutty Selva Nandakumar 1 , Kui Cheng 1
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Imidazole has an important five-membered aromatic heterocyclic ring, which is available widely in natural products and synthetic molecules. The special structural characteristics of imidazole ring enable it to bind with a variety of enzymes and receptors through hydrogen bonds, coordination, ion-dipole and cation-π interactions, hydrophobic effects, and Van der Waals forces. These interactions promote several biological activities involving anti-tumor, anti-inflammatory, anti-microbial, and anti-viral properties. Herein, we review and discuss recent developments in using imidazole derivatives and their special pharmacological activities for the treatment of various diseases.
中文翻译：
治疗药物开发中基于咪唑支架的化合物
咪唑具有重要的五元芳香杂环，广泛存在于天然产物和合成分子中。咪唑环的特殊结构特性使其能够通过氢键、配位、离子-偶极子和阳离子-π相互作用、疏水效应和范德华力与多种酶和受体结合。这些相互作用促进了几种生物活性，包括抗肿瘤、抗炎、抗微生物和抗病毒特性。在此，我们回顾和讨论了使用咪唑衍生物及其特殊药理活性治疗各种疾病的最新进展。
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