A mineralization strategy based on T-cell membrane coated CaCO3 nanoparticles against breast cancer and metastasis,Materials Chemistry Frontiers

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A mineralization strategy based on T-cell membrane coated CaCO3 nanoparticles against breast cancer and metastasis
Materials Chemistry Frontiers ( IF 6.0 ) Pub Date : 2021-6-3 , DOI: 10.1039/d1qm00464f
Yanhua Li _{1,

2,

3,

4,

5} , Xia Zhang _{1,

2,

3,

4,

5} , Xiaohan Liu _{1,

2,

3,

4,

5} , Wei Pan _{1,

2,

3,

4,

5} , Na Li _{1,

2,

3,

4,

5} , Bo Tang _{1,

2,

3,

4,

5}

Affiliation

Chemotherapy has always been ineffective against cancer metastasis due to the limited diffusion ability of passive agents into the internal tumor. Herein, we designed a mineralization strategy based on multifunctional calcium carbonate nanoparticles (CaFAM) for treating breast cancer and inhibiting metastasis. CaFAM consisted of CaCO₃ nanoparticles loaded with folic acid molecules (FA) and coated with the T-cell membrane. In the acidic tumor microenvironment, CaCO₃ disintegrates to release calcium ions (Ca²⁺) and FA. The released FA molecules conjugate to cancer cells by folate receptors, and then mediate Ca²⁺ to mineralize, which results in the suppression of migration, invasion and proliferation of cancer cells. Particularly, the T-cell membrane gives materials the ability to target tumors and avoids the immune clearance of the body. The tumor treatment results demonstrate that CaFAM provides a potential method for tumor treatment.

中文翻译：

基于 T 细胞膜包覆 CaCO3 纳米颗粒的矿化策略对乳腺癌和转移

由于被动药物进入内部肿瘤的扩散能力有限，化疗一直对癌症转移无效。在此，我们设计了一种基于多功能碳酸钙纳米粒子（CaFAM）的矿化策略，用于治疗乳腺癌和抑制转移。CaFAM 由装载有叶酸分子 (FA) 并涂有 T 细胞膜的 CaCO ₃纳米颗粒组成。在酸性肿瘤微环境中，CaCO ₃分解释放钙离子（Ca ²⁺）和FA。释放的 FA 分子通过叶酸受体与癌细胞结合，然后介导 Ca ²⁺矿化，从而抑制癌细胞的迁移、侵袭和增殖。特别是，T 细胞膜使材料能够靶向肿瘤并避免身体的免疫清除。肿瘤治疗结果表明，CaFAM 为肿瘤治疗提供了一种潜在的方法。

更新日期：2021-06-22

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