Fully Substituted Conjugate Benzofuran Core: Multiyne Cascade Coupling and Oxidation of Cyclopropenone,Organic Letters

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Fully Substituted Conjugate Benzofuran Core: Multiyne Cascade Coupling and Oxidation of Cyclopropenone
Organic Letters ( IF 4.9 ) Pub Date : 2021-06-11 , DOI: 10.1021/acs.orglett.1c01304
Liangliang Yao ₁ , Qiong Hu ₁ , Li Bao ₁ , Wenjing Zhu ₁ , Yimin Hu ₁

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An unprecedented C═C double bond cleavage of cyclopropenone and dioxygen activation by multiyne cascade coupling has been developed. This chemistry provides a novel, simple, and efficient approach to synthesize fully substituted conjugate benzofuran derivatives from simple substrates under mild conditions. The density functional theory (DFT) calculations reveal that the unique homolytic cleavages of cyclopropenone and molecular oxygen are crucial to the success of this reaction.

中文翻译：

完全取代的共轭苯并呋喃核：环丙烯酮的多炔级联偶联和氧化

已经开发了一种前所未有的环丙烯酮的 C=C 双键裂解和多炔级联偶联的双氧活化。这种化学方法提供了一种新颖、简单且有效的方法，可以在温和条件下从简单的底物合成完全取代的共轭苯并呋喃衍生物。密度泛函理论 (DFT) 计算表明，环丙烯酮和分子氧的独特均裂对该反应的成功至关重要。

更新日期：2021-07-02

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