Self-Assembly Behavior of Elastin-like Polypeptide Diblock Copolymers Containing a Charged Moiety,Biomacromolecules

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Self-Assembly Behavior of Elastin-like Polypeptide Diblock Copolymers Containing a Charged Moiety
Biomacromolecules ( IF 5.5 ) Pub Date : 2021-05-26 , DOI: 10.1021/acs.biomac.1c00322
Jeong-Wan Choi ₁ , Soo-Hyung Choi ₁ , Jong-In Won ₁

Affiliation

Elastin-like polypeptides (ELPs) are stimulus-responsive protein-based biopolymers, and some ELP block copolymers can assemble into spherical nanoparticles with thermosensitivity. In this study, two different ELP diblock copolymers, each composed of a hydrophobic and a charged moiety, were synthesized, and the dependence of their physical properties on pH, temperature, and salt concentration was investigated. A series of analyses revealed that hydrophobic core micelles could be generated in response to a change in their surroundings and that micelles did not self-aggregate, a phenomenon due to the repulsive forces between like-charged molecules on the surface. We also demonstrated that self-assembly behavior was closely dependent on the character of the charged amino acid and the specific anion in solution.

中文翻译：

含有带电部分的弹性蛋白样多肽二嵌段共聚物的自组装行为

弹性蛋白样多肽 (ELPs) 是一种刺激响应性蛋白质生物聚合物，一些 ELP 嵌段共聚物可以组装成具有热敏感性的球形纳米颗粒。在本研究中，合成了两种不同的 ELP 双嵌段共聚物，每种共聚物均由疏水部分和带电部分组成，并研究了它们的物理性质对 pH、温度和盐浓度的依赖性。一系列分析表明，疏水核胶束可以响应其周围环境的变化而产生，并且胶束不会自聚集，这是由于表面带相同电荷的分子之间的排斥力所致。我们还证明了自组装行为与带电氨基酸的特性和溶液中的特定阴离子密切相关。

更新日期：2021-06-14

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