Self-Assembly of Peptide Hierarchical Helical Arrays with Sequence-Encoded Circularly Polarized Luminescence,Nano Letters

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Self-Assembly of Peptide Hierarchical Helical Arrays with Sequence-Encoded Circularly Polarized Luminescence
Nano Letters ( IF 9.6 ) Pub Date : 2021-05-20 , DOI: 10.1021/acs.nanolett.1c00697
Qing Li ₁ , Jiaxing Zhang ₁ , Yuefei Wang _{1,

2} , Gong Zhang ₁ , Wei Qi _{1,

2,

3} , Shengping You _{1,

2} , Rongxin Su _{1,

2,

3} , Zhimin He ₁

Affiliation

Self-assembled peptide materials with sequence-encoded properties have attracted great interest. Despite their intrinsic chirality, the generation of circularly polarized luminescence (CPL) based on the self-assembly of simple peptides has been rarely reported. Here, we report the self-assembly of peptides into hierarchical helical arrays (HHAs) with controlled supramolecular handedness. The HHAs can emit full-color CPL signals after the incorporation of various achiral fluorescent molecules, and the g_lum value is 40 times higher than that of the CPL signal from the solutions. By simply changing the amino acid sequence of the peptides, CPL signals with opposite handedness can be generated within the HHAs. The peptide HHAs can provide hydrophobic pockets to accommodate the fluorescent molecules with helical arrangement through strong aromatic stacking interactions, which are responsible for the CPL signals. This work provides a pathway to construct highly ordered chiral materials, which have broad applications in the chiroptical field.

中文翻译：

具有序列编码圆偏振发光的肽分层螺旋阵列的自组装

具有序列编码特性的自组装肽材料引起了极大的兴趣。尽管它们具有内在手性，但很少报道基于简单肽的自组装产生圆偏振发光 (CPL)。在这里，我们报告了肽自组装成具有受控超分子手性的分层螺旋阵列（HHA）。所述HHAs可以各种非手性荧光分子的引入，并且经过发射全色CPL信号克_LUM值比来自溶液的 CPL 信号的值高 40 倍。通过简单地改变肽的氨基酸序列，可以在 HHA 内产生具有相反手性的 CPL 信号。肽 HHA 可以提供疏水口袋，通过强烈的芳香堆积相互作用容纳具有螺旋排列的荧光分子，这是 CPL 信号的原因。这项工作为构建高度有序的手性材料提供了一条途径，该材料在手性光学领域具有广泛的应用。

更新日期：2021-05-20

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