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Exploring End-Group Effect of Alkanethiol Self-Assembled Monolayers on Electrochemical Aptamer-Based Sensors in Biological Fluids
Analytical Chemistry ( IF 6.7 ) Pub Date : 2021-03-31 , DOI: 10.1021/acs.analchem.1c00085 Shaoguang Li 1 , Yuanyuan Wang 1 , Zishuo Zhang 1 , Yiming Wang 1 , Hui Li 1 , Fan Xia 1
Analytical Chemistry ( IF 6.7 ) Pub Date : 2021-03-31 , DOI: 10.1021/acs.analchem.1c00085 Shaoguang Li 1 , Yuanyuan Wang 1 , Zishuo Zhang 1 , Yiming Wang 1 , Hui Li 1 , Fan Xia 1
Affiliation
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The continuous, real-time monitoring of specific analytes in situ in biological fluids would provide personalized, high-precision pharmacokinetic information for the goal of precision medicine. Due to their conformationally linked signaling mechanism, electrochemical aptamer-based (E-AB) sensors are promising candidates for accurate measurements in such complex media. They suffer, however, from severe baseline drift when interrogated continuously and in real-time manner. In response, here, we investigate a couple of self-assembled monolayers in the application of E-AB sensors, achieving the improvement of their baseline stability and simultaneous modulation of sensor performance, e.g., target affinity and specificity.
中文翻译：
探索烷硫醇自组装单层对生物流体中基于电化学适体的传感器的端基作用。
对生物流体中原位特定分析物的连续，实时监控将为精密医学的目标提供个性化的高精度药代动力学信息。由于其构象连锁的信号传导机制，基于电化学适体的（E-AB）传感器是在这种复杂介质中进行精确测量的有希望的候选者。然而，当连续且实时地对其进行询问时，它们遭受严重的基线漂移的困扰。作为回应，在这里，我们研究了E-AB传感器在应用中的一些自组装单层膜，从而提高了它们的基线稳定性并同时调节了传感器的性能，例如目标亲和力和特异性。
更新日期：2021-04-13
中文翻译：
探索烷硫醇自组装单层对生物流体中基于电化学适体的传感器的端基作用。
对生物流体中原位特定分析物的连续，实时监控将为精密医学的目标提供个性化的高精度药代动力学信息。由于其构象连锁的信号传导机制，基于电化学适体的（E-AB）传感器是在这种复杂介质中进行精确测量的有希望的候选者。然而，当连续且实时地对其进行询问时，它们遭受严重的基线漂移的困扰。作为回应，在这里，我们研究了E-AB传感器在应用中的一些自组装单层膜，从而提高了它们的基线稳定性并同时调节了传感器的性能，例如目标亲和力和特异性。
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