Sensitizing DNA Towards Low‐Energy Electrons with 2‐Fluoroadenine,Angewandte Chemie International Edition

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Sensitizing DNA Towards Low‐Energy Electrons with 2‐Fluoroadenine
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2016-08-02 , DOI: 10.1002/anie.201603464
Jenny Rackwitz ₁ , Janina Kopyra ₂ , Iwona Dąbkowska ₃ , Kenny Ebel ₁ , MiloŠ Lj. Ranković ₄ , Aleksandar R. Milosavljević _{4,

5} , Ilko Bald _{1,

6}

Affiliation

2‐Fluoroadenine (^2FA) is a therapeutic agent, which is suggested for application in cancer radiotherapy. The molecular mechanism of DNA radiation damage can be ascribed to a significant extent to the action of low‐energy (<20 eV) electrons (LEEs), which damage DNA by dissociative electron attachment. LEE induced reactions in ^2FA are characterized both isolated in the gas phase and in the condensed phase when it is incorporated into DNA. Information about negative ion resonances and anion‐mediated fragmentation reactions is combined with an absolute quantification of DNA strand breaks in ^2FA‐containing oligonucleotides upon irradiation with LEEs. The incorporation of ^2FA into DNA results in an enhanced strand breakage. The strand‐break cross sections are clearly energy dependent, whereas the strand‐break enhancements by ^2FA at 5.5, 10, and 15 eV are very similar. Thus, ^2FA can be considered an effective radiosensitizer operative at a wide range of electron energies.

中文翻译：

使用2氟丁烯碱将DNA朝低能电子敏感

2-氟代肾上腺素（^2F A）是一种治疗剂，建议用于癌症放射治疗中。DNA辐射损伤的分子机制在很大程度上可归因于低能（<20 eV）电子（LEE）的作用，该电子通过解离电子附着而损伤DNA。当将其掺入DNA中时，LEE诱导的^2FA中的反应既可以在气相中分离，也可以在浓缩相中分离。约负离子共振和阴离子介导的断裂反应的信息与DNA链断裂在绝对量化组合^2F含A-照射时用的寡核苷酸的LEE。^2F的成立DNA进入A导致链断裂增强。链断裂的横截面显然取决于能量，而^2F A在5.5、10和15 eV时的链断裂增强非常相似。因此，可以认为^2FA可以在很宽的电子能量范围内起作用。

更新日期：2016-08-02

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