The sustained interest in the synthesis of new analogues of 2,2′-bipyridines is supported by the importance of compounds featuring bipyridine core in diverse areas of chemical, biomedical and materials research, which is relayed into the development of new approaches and the expansion of existing synthetic methods. This short review covers advances in the synthesis of 2,2′-bipyridines, including both the synthesis of compounds with a given substitution pattern and the development of new methods for assembling the bipyridine core. Special attention is directed toward the use of pyridine N-oxides and metal-free protocols to facilitate the formation of bipyridines. This short review focuses primarily on reports published in the last 5–6 years.

1 Introduction

2 Ullmann-Type Homocoupling Reactions

3 Cross-Coupling Reactions in the Synthesis of Bipyridines

4 Coupling Reactions Employing Pyridine N-Oxides

5 Other Methods for the Synthesis of 2,2′-Bipyridines

6 Conclusions and Outlook

在化学，生物医学和材料研究的各个领域，具有联吡啶核心的化合物的重要性支持了对合成2,2'-联吡啶的新类似物的持续兴趣，这些化合物又被转嫁到新方法的开发和扩展中。现有的合成方法。这篇简短的综述涵盖了2,2'-联吡啶的合成进展，包括具有给定取代模式的化合物的合成以及组装联吡啶核心的新方法的开发。特别注意使用吡啶N-氧化物和无金属方案以促进联吡啶的形成。这篇简短的评论主要关注最近5至6年内发布的报告。

1引言

2 Ullmann型均相偶联反应

联吡啶合成中的3个交叉偶联反应

使用吡啶N-氧化物的4种偶联反应

5其他合成2,2'-联吡啶的方法

6结论与展望