Abstract

Liver sinusoidal endothelial cells (LSECs) are the gatekeeper of liver to maintain hepatic homeostasis. They are formed into the highly specialized endothelium between vascular lumen and the space of Disse and are mechanosensitive to respond varied microenvironments. Shear stress and mechanical stretch induced by blood perfusion and substrate stiffness enhancement derived from deposition of extracellular matrix (ECM) are major mechanical stimuli that surround LSECs. This review introduces how LSECs respond to the external forces in both physiological and pathological cases and what is the interplay of LSECs with other hepatic cells. Molecular mechanisms that potentiate LSECs mechanotransduction are also discussed.

Graphic abstract

中文翻译：

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各种机械刺激下肝窦内皮细胞的机械转导

摘要

肝窦窦内皮细胞（LSEC）是肝脏维持肝稳态的守门人。它们形成在血管腔和Disse空间之间的高度专业化的内皮中，并且对各种微环境都具有机械敏感性。由血液灌注引起的剪切应力和机械拉伸以及源自细胞外基质（ECM）沉积的底物刚度增强是围绕LSEC的主要机械刺激。这篇综述介绍了LSEC在生理和病理情况下如何响应外力，以及LSEC与其他肝细胞之间的相互作用是什么。还讨论了增强LSECs机械转导的分子机制。

图形摘要