Physiological effects of tangeretin and heptamethoxyflavone on obese C57BL/6J mice fed a high‐fat diet and analyses of the metabolites originating from these two polymethoxylated flavones,Food Science & Nutrition

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Physiological effects of tangeretin and heptamethoxyflavone on obese C57BL/6J mice fed a high‐fat diet and analyses of the metabolites originating from these two polymethoxylated flavones
Food Science & Nutrition ( IF 3.5 ) Pub Date : 2021-02-12 , DOI: 10.1002/fsn3.2167
Marina Nery ₁ , Paula S Ferreira _{1,

2} , Danielle R Gonçalves _{1,

2} , Luis C Spolidorio ₃ , John A Manthey ₂ , Thais B Cesar ₁

Affiliation

Two compounds from citrus peel, tangeretin (TAN) and 3′,4′,3,5,6,7,8‐heptamethoxyflavone (HMF), were investigated for their abilities to repair metabolic damages caused by an high‐fat diet (HFD) in C57BL/6J mice. In the first 4 weeks, mice were fed either a standard diet (11% kcal from fat) for the control group, or a HFD (45% kcal from fat) to establish obesity in three experimental groups. In the following 4 weeks, two groups receiving the HFD were supplemented with either TAN or HMF at daily doses of 100 mg/kg body weight, while the two remaining groups continued to receive the standard healthy diet or the nonsupplemented HFD. Four weeks of supplementation with TAN and HMF resulted in intermediate levels of blood serum glucose, leptin, resistin, and insulin resistance compared with the healthy control and the nonsupplemented HFD groups. Blood serum peroxidation (TBARS) levels were significantly lower in the TAN and HMF groups compared with the nonsupplemented HFD group. Several differences occurred in the physiological effects of HMF versus TAN. TAN, but not HMF, reduced adipocyte size in the mice with pre‐existent obesity, while HMF, but not TAN, decreased fat accumulation in the liver and also significantly increased the levels of an anti‐inflammatory cytokine, IL‐10. In an analysis of the metabolites of TAN and HMF, several main classes occurred, including a new set of methylglucuronide conjugates. It is suggested that contrasts between the observed physiological effects of TAN and HMF may be attributable to the differences in numbers and chemical structures of TAN and HMF metabolites.

中文翻译：

橘皮素和七甲氧基黄酮对高脂饮食肥胖 C57BL/6J 小鼠的生理影响及这两种多甲氧基黄酮的代谢产物分析

研究人员研究了来自柑橘皮的两种化合物，橘子素 (TAN) 和 3',4',3,5,6,7,8-七甲氧基黄酮 (HMF) 修复高脂饮食 (HFD) 引起的代谢损伤的能力。）在 C57BL/6J 小鼠中。在前 4 周内，对照组的小鼠被喂食标准饮食（11% kcal 来自脂肪），而三个实验组则被喂食 HFD（45% kcal 来自脂肪）以建立肥胖。在接下来的 4 周内，接受 HFD 的两组按每日 100 毫克/公斤体重的剂量补充 TAN 或 HMF，而其余两组继续接受标准健康饮食或不补充的 HFD。与健康对照组和未补充 HFD 组相比，补充 TAN 和 HMF 4 周后，血糖、瘦素、抵抗素和胰岛素抵抗处于中等水平。与未补充 HFD 组相比，TAN 和 HMF 组的血清过氧化 (TBARS) 水平显着降低。 HMF 与 TAN 的生理效应存在一些差异。 TAN（而非 HMF）减少了肥胖小鼠的脂肪细胞大小，而 HMF（而非 TAN）减少了肝脏中的脂肪积累，并且还显着增加了抗炎细胞因子 IL-10 的水平。在对 TAN 和 HMF 代谢物的分析中，出现了几个主要类别，包括一组新的甲基葡萄糖醛酸结合物。这表明观察到的 TAN 和 HMF 生理效应之间的对比可能归因于 TAN 和 HMF 代谢物数量和化学结构的差异。

更新日期：2021-04-05

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