Solvent‐Free Single‐Pot Mannich Reaction and Detoxification of Industrial Hazardous Waste Methyl Mercaptan Gas,ChemistrySelect

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Solvent‐Free Single‐Pot Mannich Reaction and Detoxification of Industrial Hazardous Waste Methyl Mercaptan Gas
ChemistrySelect ( IF 1.9 ) Pub Date : 2021-02-03 , DOI: 10.1002/slct.202004447
Sharada Prasanna Swain _{1,

2} , Nagendra Prasad ₁ , Latchi Reddy ₁ , G. Subrahmanyam ₁ , Sandeep Mohanty ₁

Affiliation

Environment pollution is causing serious human health issues and forest deterioration. Methyl mercaptan is a malodorous gaseous pollutant, which is a by product of sewage treatment plants, pulp plants, petrochemical plants, agrochemicals, and some pharmaceutical products. A long term exposure to methyl mercaptan may lead to adverse effects on central nervous system and cardiovascular system. The pharmaceutical industries are devoting significant efforts to develop process by using green solvents like water, and develop solvent‐free reactions. This will help to develop green, sustainable methods for the synthesis of API and reduce the manufacturing cost. A ZnCl₂ catalyzed solvent‐free, one‐pot process for the synthesis of ranitidine and quenching of hazardous waste methyl mercaptan gas to a useful product have been developed.

中文翻译：

无溶剂单锅曼尼希反应和工业危险废物甲基硫醇气体的解毒

环境污染正在引起严重的人类健康问题和森林退化。甲硫醇是一种恶臭的气态污染物，是污水处理厂，纸浆厂，石化厂，农用化学品和某些医药产品的副产品。长期接触甲硫醇可能会对中枢神经系统和心血管系统产生不利影响。制药行业致力于通过使用绿色溶剂（例如水）来开发工艺，并开发无溶剂反应。这将有助于开发绿色，可持续的API合成方法，并降低制造成本。ZnCl ₂ 已开发出一种催化无溶剂的单锅法，用于合成雷尼替丁和将危险的甲硫醇废料气体淬灭成有用的产品。

更新日期：2021-02-03

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