Metal–Organic Frameworks for Preserving the Functionality of Plasmonic Nanosensors,ACS Applied Materials & Interfaces

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Metal–Organic Frameworks for Preserving the Functionality of Plasmonic Nanosensors
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-01-26 , DOI: 10.1021/acsami.0c20390
Yixuan Li ₁ , Heng Guo ₁ , Ze Yin ₁ , Kendahl Lyle ₁ , Limei Tian ₁

Affiliation

Preserving the functionality of nanosensors is critical for their reliable performance under harsh environmental conditions. Biofunctionalized plasmonic nanostructures are an important class of bionanoconjugates for biosensing, bioimaging, and nanotherapeutics. Plasmonic nanostructures and biomolecules exhibit poor thermal stability over time. Here, we report a class of metal–organic framework, zeolitic imidazolate framework-8 (ZIF-8), as a protective coating for preserving plasmonic nanostructures and plasmonic bionanoconjugates at elevated temperature. Gold nanobipyramids (AuNBPs) with sharp tips are attractive plasmonic nanotransducers with high sensitivity but are prone to structural change and loss of sensitivity. This work reports the first observation that ZIF-8 can preserve the structure of AuNBPs and their corresponding strong electromagnetic field enhancement and high refractive index sensitivity. In addition, ZIF-8 coating enables nearly 100% retention of biorecognition capability of antibodies immobilized on the AuNBP surface after exposure to 60 °C for 48 h. The efficacy, versatility, and facile implementation of ZIF-8 coating offer great promise for the preservation of nanosensors.

中文翻译：

用于保持等离子体纳米传感器功能的金属-有机框架

保持纳米传感器的功能对于它们在恶劣环境条件下的可靠性能至关重要。生物功能化等离子体纳米结构是一类重要的生物纳米偶联物，用于生物传感、生物成像和纳米治疗。随着时间的推移，等离子体纳米结构和生物分子表现出较差的热稳定性。在这里，我们报告了一类金属-有机骨架，沸石咪唑骨架-8（ZIF-8），作为在高温下保护等离子体纳米结构和等离子体生物纳米共轭物的保护涂层。具有尖锐尖端的金纳米双锥 (AuNBP) 是具有高灵敏度的有吸引力的等离子体纳米传感器，但容易发生结构变化和灵敏度损失。这项工作报告了第一个观察结果，即 ZIF-8 可以保留 AuNBP 的结构及其相应的强电磁场增强和高折射率敏感性。此外，ZIF-8 涂层使固定在 AuNBP 表面的抗体在暴露于 60°C 48 小时后几乎 100% 保持生物识别能力。ZIF-8 涂层的功效、多功能性和简便的实施为纳米传感器的保存提供了广阔的前景。

更新日期：2021-02-03

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