Therapeutic Mechanism of Nucleic Acid Drugs,ChemistrySelect

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Therapeutic Mechanism of Nucleic Acid Drugs
ChemistrySelect ( IF 1.9 ) Pub Date : 2021-01-26 , DOI: 10.1002/slct.202002901
Lianxiao Liu ₁ , Haixia Gao ₁ , Chuanxin Guo ₁ , Tao Liu ₁ , Ning Li ₁ , Qijun Qian ₁

Affiliation

Nucleic acid drugs were a class of DNA/RNA molecules and considered able to be applied for protein‐related diseases treatment through regulating target proteins expression. A number of nucleic acid drugs have been approved for treating various disease, caused by genetic defects, viral infections and genetic mutations. Based on different structural characteristics, this review provided a comprehensive overview about the nucleic acid drug's medicinal mechanism, clinical development, application, and also discussed the opportunities and challenges in nucleic acid drugs development.

中文翻译：

核酸药物的治疗机制

核酸药物是一类DNA / RNA分子，被认为能够通过调节靶蛋白的表达而应用于蛋白相关疾病的治疗。已经批准了许多核酸药物用于治疗由遗传缺陷，病毒感染和遗传突变引起的各种疾病。基于不同的结构特征，本综述对核酸药物的药物作用机理，临床开发，应用进行了全面综述，并探讨了核酸药物开发中的机遇与挑战。

更新日期：2021-01-26

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