肽工程荧光纳米材料：结构设计，功能定制和生物医学应用,Small

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肽工程荧光纳米材料：结构设计，功能定制和生物医学应用
Small ( IF 13.0 ) Pub Date : 2021-01-15 , DOI: 10.1002/smll.202005578
Yan Wang ₁ , Kai Xia ₁ , Luchen Wang ₂ , Mingxue Wu ₁ , Xiujie Sang ₃ , Keming Wan ₁ , Xiaodong Zhang ₁ , Xiaomin Liu ₁ , Gang Wei _{1,

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Affiliation

荧光纳米材料在生物医学和组织工程领域已显示出有希望的应用。为了改善荧光纳米材料的特性并扩大其在生物学上的应用，已经采用了各种功能化和生物修饰策略来设计荧光纳米材料的结构和功能。由于它们的高生物相容性，令人满意的生物活性，独特的仿生功能，容易的结构剪裁和可控的自组装能力，超分子肽被广泛用作工程荧光纳米材料的多功能改性剂和纳米级构建基块。在这项工作中，介绍了肽工程荧光纳米材料的合成，结构，功能和生物医学应用的最新进展。首先，介绍了不同类型的荧光纳米材料。然后，讨论了通过模板合成，生物启发的偶联和肽组装辅助合成制备肽工程荧光纳米材料的潜在策略。此后，通过与荧光纳米材料的肽缀合展示了独特的结构和功能。最后，对肽工程荧光纳米材料在生物成像，疾病诊断和治疗，药物输送，组织工程，抗微生物测试和生物传感中的生物医学应用进行了介绍和讨论。有助于读者理解基于肽的荧光纳米材料的结合和生物启发性合成，

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Peptide‐Engineered Fluorescent Nanomaterials: Structure Design, Function Tailoring, and Biomedical Applications

Fluorescent nanomaterials have exhibited promising applications in biomedical and tissue engineering fields. To improve the properties and expand bioapplications of fluorescent nanomaterials, various functionalization and biomodification strategies have been utilized to engineer the structure and function of fluorescent nanomaterials. Due to their high biocompatibility, satisfied bioactivity, unique biomimetic function, easy structural tailoring, and controlled self‐assembly ability, supramolecular peptides are widely used as versatile modification agents and nanoscale building blocks for engineering fluorescent nanomaterials. In this work, recent advance in the synthesis, structure, function, and biomedical applications of peptide‐engineered fluorescent nanomaterials is presented. Firstly, the types of different fluorescent nanomaterials are introduced. Then, potential strategies for the preparation of peptide‐engineered fluorescent nanomaterials via templated synthesis, bioinspired conjugation, and peptide assembly‐assisted synthesis are discussed. After that, the unique structure and functions through the peptide conjugation with fluorescent nanomaterials are demonstrated. Finally, the biomedical applications of peptide‐engineered fluorescent nanomaterials in bioimaging, disease diagnostics and therapy, drug delivery, tissue engineering, antimicrobial test, and biosensing are presented and discussed in detail. It is helpful for readers to understand the peptide‐based conjugation and bioinspired synthesis of fluorescent nanomaterials, and to design and synthesize novel hybrid bionanomaterials with special structures and improved functions for advanced applications.

更新日期：2021-02-05

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