1979年至2018年安大路西亚皮肤恶性黑色素瘤的死亡率。有新观点吗？,Dermatologic Therapy

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1979年至2018年安大路西亚皮肤恶性黑色素瘤的死亡率。有新观点吗？
Dermatologic Therapy ( IF 3.7 ) Pub Date : 2020-12-26 , DOI: 10.1111/dth.14715
Juan Ortiz‐Álvarez ₁ , Antonio José Durán‐Romero ₁ , Juan Carlos Hernández‐Rodríguez ₁ , Mercedes Sendín‐Martin ₁ , Julian Conejo‐Mir _{1,

2} , José‐Juan Pereyra‐Rodriguez _{1,

2}

Affiliation

恶性黑色素瘤占皮肤癌死亡人数的80％。其发病率正在全球范围内增加。但是，黑色素瘤的死亡率似乎正在下降。这项研究的目的是分析1979年至2018年间安达卢西亚的黑素瘤导致的死亡率。安达卢西亚的黑素瘤和中年人口死亡是从国家统计局收集的。计算了总人口以及每个性别和年龄组的年龄调整死亡率。回归模型用于计算重要的变化点。还分析了性别比以及年龄，时期和队列的独立影响。从1979年到2018年，总人口的黑素瘤年龄调整死亡率从每100.000例死亡0.61例上升到1.94例。从1979年开始稳步上升之后，1994年左右发现了趋势的重大变化，死亡率一直稳定到研究期末。在> 64岁的男性中，引证的增加更为明显。从2000年代末开始，所有人群的死亡率迄今都在下降，产生了时期效应。从1994年开始，安达卢西亚的黑素瘤死亡率趋于稳定，而在21世纪初某些群体的黑素瘤死亡率有所下降。在安达卢西亚观察到的趋势与西班牙没有太大的不同。新疗法的发展和早期诊断可能会对这些变化产生影响。需要进行比较西班牙地区之间差异的研究，以定义更好的预防策略。迄今为止，所有人群的死亡率均下降，产生了时期效应。从1994年开始，安达卢西亚的黑素瘤死亡率趋于稳定，而在21世纪初某些群体的黑素瘤死亡率有所下降。在安达卢西亚观察到的趋势与西班牙没有太大的不同。新疗法的发展和早期诊断可能会对这些变化产生影响。需要进行比较西班牙地区之间差异的研究，以定义更好的预防策略。迄今为止，所有人群的死亡率均下降，产生了时期效应。从1994年开始，安达卢西亚的黑素瘤死亡率稳定下来，而在21世纪初期某些群体的黑素瘤死亡率有所下降。在安达卢西亚观察到的趋势与西班牙没有太大的不同。新疗法的发展和早期诊断可能会对这些变化产生影响。需要进行比较西班牙地区之间差异的研究，以定义更好的预防策略。新疗法的发展和早期诊断可能会对这些变化产生影响。需要进行比较西班牙地区之间差异的研究，以制定更好的预防策略。新疗法的发展和早期诊断可能会对这些变化产生影响。需要进行比较西班牙地区之间差异的研究，以定义更好的预防策略。

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Cutaneous malignant melanoma mortality in Andalusia from 1979 to 2018. Toward new perspectives?

Malignant melanoma accounts for 80% of deaths due to skin cancer. Its incidence is globally increasing. However, melanoma mortality seems to be decreasing. The aim of this study was to analyze mortality rates due to melanoma in Andalusia between 1979 and 2018. Deaths due to melanoma and mid‐year population in Andalusia were collected from the National Institute of Statistics. Age‐adjusted mortality rates were calculated for overall population and for each sex and age group. Regression models were used to calculate significant points of change. Sex ratio and the independent effects of age, period, and cohort were also analyzed. Age‐adjusted mortality due to melanoma rose from 0.61 to 1.94 deaths per 100.000 from 1979 to 2018 for the overall population. A significant change of trends was detected around 1994 when, after a steady rise from 1979, mortality rates stabilized up to the end of the period studied. The cited increase was more pronounced in >64 year males. From the end of the 2000s, there was a decrease in mortality rates to date in all population groups, producing a period effect. A stabilization in melanoma mortality rates was observed in Andalusia from 1994 with a decrease in some groups at the beginning of the 21st century. Trends observed in Andalusia do not differ substantially from those in Spain. The development of new therapies and an earlier diagnosis may have an influence in those changes. Studies that compare differences between Spanish regions are needed to define better prevention strategies.

更新日期：2021-02-11

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