Inorganic Nanoparticles Applied as Functional Therapeutics,Advanced Functional Materials

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Inorganic Nanoparticles Applied as Functional Therapeutics
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-12-04 , DOI: 10.1002/adfm.202008171
Qianqian Liu _{1,

2} , Yu‐Jin Kim ₃ , Gwang‐Bum Im ₃ , Jintao Zhu ₂ , Yuzhou Wu ₁ , Yijing Liu ₁ , Suk Ho Bhang ₃

Affiliation

Inorganic nanoparticles (NPs) offer significant advantages to the biomedical field owing to their large surface area, controllable structures, diverse surface chemistry, and unique optical and physical properties. Researchers worldwide have shown that inorganic NPs and the released metal ions can act as therapeutic agents in targeted tissues or to cure various diseases without acute toxicity. In this progress report, the recent developments in inorganic NPs with different compositions directly used as therapeutics are discussed. First, the recent convergence of nanotechnology and biotechnology in biomedical applications as well as the unique functions, features, and advantages of inorganic NPs in biomedical applications are summarized. Thereafter, the biological effects of inorganic compositions in NPs which include balancing the intracellular redox environment, regulating the specific cellular signaling and cellular behaviors, and apoptosis are explained. In addition, the emerging therapeutic applications of inorganic NPs in various diseases are exemplified. Finally, the perspectives and challenges for overcoming the weaknesses of inorganic NPs as therapeutics are discussed. By carefully considering and investigating the biological effects of inorganic NPs and metal ions released from NPs, more promising inorganic NPs based therapeutic agents can be developed.

中文翻译：

无机纳米颗粒用作功能治疗剂

无机纳米粒子（NPs）由于其较大的表面积，可控的结构，多样的表面化学以及独特的光学和物理特性，为生物医学领域提供了显着的优势。全世界的研究人员已经表明，无机NP和释放的金属离子可以在目标组织中充当治疗剂，或治愈各种疾病而无急性毒性。在该进展报告中，讨论了直接用作治疗剂的具有不同组成的无机NP的最新发展。首先，总结了纳米技术和生物技术在生物医学应用中的最新融合以及无机NP在生物医学应用中的独特功能，特征和优势。之后，解释了NPs中无机成分的生物学作用，包括平衡细胞内氧化还原环境，调节特定的细胞信号传导和细胞行为以及细胞凋亡。另外，举例说明了无机NP在各种疾病中的新兴治疗应用。最后，讨论了克服无机NP作为治疗方法的弱点的观点和挑战。通过仔细考虑和研究无机NP和从NP释放的金属离子的生物学效应，可以开发出更有前途的基于无机NP的治疗剂。讨论了克服无机NP作为治疗方法的弱点的观点和挑战。通过仔细考虑和研究无机NP和从NP释放的金属离子的生物学效应，可以开发出更有前途的基于无机NP的治疗剂。讨论了克服无机NP作为治疗方法的弱点的观点和挑战。通过仔细考虑和研究无机NP和从NP释放的金属离子的生物学效应，可以开发出更有前途的基于无机NP的治疗剂。

更新日期：2020-12-04

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