Rationally Designed Redox-Active Au(I) N-Heterocyclic Carbene: An Immunogenic Cell Death Inducer,Journal of the American Chemical Society

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Rationally Designed Redox-Active Au(I) N-Heterocyclic Carbene: An Immunogenic Cell Death Inducer
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2020-11-25 , DOI: 10.1021/jacs.0c09753
Sajal Sen ₁ , Stephanie Hufnagel ₂ , Esther Y Maier ₃ , Isaiah Aguilar ₁ , Jayaraman Selvakumar ₄ , Jennie E DeVore ₃ , Vincent M Lynch ₁ , Kuppuswamy Arumugam ₄ , Zhengrong Cui ₂ , Jonathan L Sessler ₁ , Jonathan F Arambula ₁

Affiliation

Immunogenic cell death (ICD) is a way of reengaging the tumor-specific immune system. ICD can be induced by treatment with chemotherapeutics. However, only a limited number of drugs and other treatment modalities have been shown to elicit the biomarker responses characteristic of ICD and to provide an anticancer benefit in vivo. Here, we report a rationally designed redox-active Au(I) bis-N-heterocyclic carbene that induces ICD both in vitro and in vivo. This work benefits from a synthetic pathway that allows for the facile preparation of asymmetric redox-active Au(I) bis-N-heterocyclic carbenes.

中文翻译：

合理设计的氧化还原活性 Au(I) N-杂环卡宾：一种免疫原性细胞死亡诱导剂

免疫原性细胞死亡 (ICD) 是一种重新激活肿瘤特异性免疫系统的方法。ICD 可通过化疗药物治疗诱发。然而，只有有限数量的药物和其他治疗方式已被证明可以引发 ICD 的生物标志物反应特征并在体内提供抗癌益处。在这里，我们报告了一种合理设计的氧化还原活性 Au(I) 双-N-杂环卡宾，可在体外和体内诱导 ICD。这项工作得益于一种合成途径，可以轻松制备不对称的氧化还原活性 Au(I) 双-N-杂环卡宾。

更新日期：2020-11-25

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