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From structure to function: Route to understanding lncRNA mechanism
BioEssays ( IF 3.2 ) Pub Date : 2020-11-09 , DOI: 10.1002/bies.202000027
Johannes Graf 1 , Markus Kretz 1
Affiliation  

RNAs have emerged as a major target for diagnostics and therapeutics approaches. Regulatory nonprotein‐coding RNAs (ncRNAs) in particular display remarkable versatility. They can fold into complex structures and interact with proteins, DNA, and other RNAs, thus modulating activity, localization, or interactome of multi‐protein complexes. Thus, ncRNAs confer regulatory plasticity and represent a new layer of regulatory control. Interestingly, long noncoding RNAs (lncRNAs) tend to acquire complex secondary and tertiary structures and their function—in many cases—is dependent on structural conservation rather than primary sequence conservation.

中文翻译:

从结构到功能:理解lncRNA机制的途径

RNA已经成为诊断和治疗方法的主要目标。监管性非蛋白质编码RNA(ncRNA)特别是具有非凡的多功能性。它们可以折叠成复杂的结构,并与蛋白质,DNA和其他RNA相互作用,从而调节多蛋白复合物的活性,定位或相互作用组。因此,ncRNA赋予了调节可塑性,并代表了新的调节控制层。有趣的是,长的非编码RNA(lncRNA)倾向于获得复杂的二级和三级结构,其功能(在许多情况下)取决于结构保守性而不是一级序列保守性。
更新日期:2020-11-25
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