Paper spray mass spectrometry - A potential complementary technique for the detection of polar compounds in sports drug testing.,Drug Testing and Analysis

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Paper spray mass spectrometry - A potential complementary technique for the detection of polar compounds in sports drug testing.
Drug Testing and Analysis ( IF 2.6 ) Pub Date : 2020-08-09 , DOI: 10.1002/dta.2909
Christian Görgens ₁ , Katherine Walker ₂ , Cornelia Boeser ₂ , Neloni Wijeratne ₂ , Claudia Martins ₂ , Sven Guddat ₁ , Mario Thevis _{1,

3}

Affiliation

In this proof‐of‐concept study, paper spray mass spectrometry was investigated as a high‐throughput and fully automated technique for the initial testing of particularly polar compounds that are prohibited in sports. The technique allows the ionization of analytes from complex sample matrices such as blood and urine when spotted onto a paper strip. By minimizing sample preparation and omitting chromatographic separation, paper spray mass spectrometry benefits from considerable cost‐ and time‐savings compared with conventional high performance liquid chromatography/tandem mass spectrometry, especially in cases where conventional reversed‐phase liquid chromatography offers limited applicability. All but one of the investigated model compounds fulfilled the World Anti‐Doping Agency's (WADA's) requirements regarding the applicable minimum required performance limits for initial testing procedures. In addition, the combination of paper spray mass spectrometry and ion mobility separation results in enhanced selectivity and sensitivity and is a particularly valuable analytical configuration.

中文翻译：

纸喷雾质谱 - 在运动药物测试中检测极性化合物的潜在补充技术。

在这项概念验证研究中，纸喷雾质谱作为一种高通量和全自动技术进行了研究，用于对运动中禁用的特别极性化合物进行初步测试。该技术允许将复杂样品基质（如血液和尿液）中的分析物点在纸条上时进行电离。通过最大限度地减少样品制备和省略色谱分离，与传统的高效液相色谱/串联质谱相比，纸喷雾质谱可节省大量成本和时间，尤其是在传统反相液相色谱适用性有限的情况下。除了一种被研究的模型化合物外，其他所有化合物都符合世界反兴奋剂机构 (WADA' s) 关于初始测试程序适用的最低要求性能限制的要求。此外，纸喷雾质谱和离子淌度分离的结合提高了选择性和灵敏度，是一种特别有价值的分析配置。

更新日期：2020-08-09

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